Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study Journal Article


Authors: Mensah, N. Y.; Peterlongo, P.; Steinherz, P.; Pamer, E. G.; Satagopan, J.; Papanicolaou, G. A.
Article Title: Toll-like receptor 4 polymorphisms and risk of gram-negative bacteremia after allogeneic stem cell transplantation. A prospective pilot study
Abstract: The Toll-like receptor 4 (TLR4) gene is a major recognition receptor for lipopolysaccharide (LPS). In a pilot prospective study, we examined the association of 2 TLR4 polymorphisms (Asp299Gly and Thr399Ile) in the donor or the recipient with Gram-negative bloodstream infection (BSI) in 77 allogeneic hematopoietic stem cell transplant (HSCT) patients. Heterozygosity at both loci was defined as "risk genotype." The cumulative incidence of infection was estimated by treating death prior to infection as a competing risk event and compared between relevant groups using a modified chi-square test. Nine patients had the risk genotype based on donor and 5 based on recipient genotype data. Donor risk genotype showed marginal statistical significance (0.06) in univariate analysis, but not in multivariate analysis. A larger study is required to validate our findings and define genetic susceptibility to this serious infection in HSTC patients. © 2009 American Society for Blood and Marrow Transplantation.
Keywords: antibiotic agent; transplantation, homologous; major clinical study; mutation; polymorphism, single nucleotide; allogeneic stem cell transplantation; clinical trial; mortality; prospective studies; genetic predisposition to disease; incidence; gene locus; genotype; hematopoietic stem cell transplantation; risk assessment; toll like receptor 4; pilot study; pilot projects; heterozygosity; genetic susceptibility; nucleotide sequence; innate immunity; threonine; multivariate analysis; bacteremia; genetic risk; bone marrow transplantation; infection risk; toll-like receptor; glycine; asparagine; polymorphism; gram-negative infection; gram negative sepsis; protein polymorphism; gram-negative bacteria; gram-negative bacterial infections; toll-like receptor 4
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 15
Issue: 9
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2009-09-01
Start Page: 1130
End Page: 1133
Language: English
DOI: 10.1016/j.bbmt.2009.04.012
PUBMED: 19660727
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 30 November 2010" - "CODEN: BBMTF" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Jaya M Satagopan
    140 Satagopan
  2. Eric Pamer
    254 Pamer
  3. Peter G Steinherz
    179 Steinherz
  4. Nana Yaa Takyiwaa Mensah
    7 Mensah