TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation Conference Paper

  


Authors: Kesh, S.; Mensah, N. Y.; Peterlongo, P.; Jaffe, D.; Hsu, K.; Van Den Brink, M.; O'reilly, R.; Pamer, E.; Satagopan, J.; Papanicolaou, G. A.
Title: TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
Conference Title: Human Immunology: Patient-Based Research
Abstract: Toll-like receptors (TLRs) transmit signals in response to Aspergillus fumigatus conidia and hyphae. In this preliminary study, we examined the association between single nucleotide polymorphisms (SNPs) in TLR1, TLR4, and TLR6 genes and development of invasive aspergillosis (IA) in 127 allogeneic hematopoietic stem cell transplant recipients consisting of 22 patients with IA and 105 unaffected control subjects. The following SNPs and their pairwise interactions were considered in the model: TLR1 (239G > C, 743A > G, 914A > T, 1805G > T), TLR4 (896A > G, 1196C > T), and TLR6 (359T > C, 745C > T, 764C > T). No association was found between donor SNP and the risk of IA. Analysis of recipient SNP data showed that the presence of TLR1 239G > C (Arg80 > Thr) or the presence of both TLR1 743A > G (Asn248 > Ser) and TLR6 745C > T (Ser249 > Pro) is associated with IA (odds ratio = 1.30, 95% confidence interval = 1.13 to 1.50; P < .001). Further analyses using a prospective cohort may enable us to identify TLR polymorphisms associated with the susceptibility to IA within a defined interval among immunocompromised patients.
Keywords: retrospective studies; transplantation, homologous; single nucleotide polymorphism; genetics; polymorphism, single nucleotide; prospective study; prospective studies; allele; genetic predisposition to disease; amino acid substitution; logistic models; alleles; hematopoietic stem cell transplantation; retrospective study; immunology; nucleotide sequence; dna mutational analysis; genetic predisposition; statistical model; aspergillosis; allotransplantation; toll like receptor 1; lung mycosis; toll like receptor 6; lung diseases, fungal; tlr6 protein, human; toll-like receptor 1; toll-like receptor 6
Journal Title Annals of the New York Academy of Sciences
Volume: 1062
Conference Dates: 2005 May 16-18
Conference Location: New York, NY
ISBN: 0077-8923
Publisher: John Wiley & Sons  
Date Published: 2005-12-01
Start Page: 95
End Page: 103
Language: English
DOI: 10.1196/annals.1358.012
PUBMED: 16461792
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33745492610&partnerID=40&md5=185d0423439c26e387bb3f5c02d99563
Notes: --- - "Cited By (since 1996): 81" - "Export Date: 24 October 2012" - "Source: Scopus" - Proceedings Paper - Conference on Human Immunology - MAY 16-18, 2005 - New York, NY - NY Acad Sci, Dana Fdn - 2 EAST 63RD ST, NEW YORK, NY 10021 USA
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MSK Authors
  1. Paolo Peterlongo
    11 Peterlongo
  2. Dana Jaffe
    13 Jaffe
  3. Sandra Kesh
    2 Kesh
  4. Jaya M Satagopan
    141 Satagopan
  5. Marcel R M Van Den Brink
    616 Van Den Brink
  6. Eric Pamer
    283 Pamer
  7. Genovefa A Papanicolaou
    238 Papanicolaou
  8. Katharine C Hsu
    184 Hsu
  9. Richard O'Reilly
    747 O'Reilly
  10. Nana Yaa Takyiwaa Mensah
    11 Mensah
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