Hematopoietic stem cell transplantation: Killer immunoglobulin-like receptor component Journal Article


Authors: Hsu, K. C.; Pinto-Agnello, C.; Gooley, T.; Malkki, M.; Dupont, B.; Petersdorf, E. W.
Article Title: Hematopoietic stem cell transplantation: Killer immunoglobulin-like receptor component
Abstract: Recognition of recipient human leukocyte antigen (HLA) class I ligand by donor natural killer cell killer immunoglobulin-like receptors (KIR) has been proposed as the basis for donor allograft reactivity against malignancy leading to reduction in posttransplant relapse and higher survival for acute myelogenous leukemia. Analysis of KIR ligand effects in 1770 patients undergoing myeloablative T-replete hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors showed that lack of KIR ligand in patients for inhibitory KIR was associated with lower hazards of relapse in leukemia patients with in HLA-mismatched transplants [hazard ratio (HR): 0.061; 95% confidence interval (CI): 0.43-0.85; P-value = 0.004]. Absence of HLA-C group 2 or HLA-Bw4 KIR ligands were each associated with lower hazards of relapse (HR: 0.47; 95% CI: 0.28-0.79; P-value = 0.004; HR: 0.56; 95% CI: 0.33-0.97; P-value = 0.04, respectively). Based on these analyses, recipient homozygosity for HLA-B or -C epitopes that define KIR ligands is likely to be a predictive factor for leukemia relapse following myeloablative HCT from unrelated donors. KIR genotyping for unrelated donors and recipients will clarify the role of these receptors in transplant outcome. © 2007 Blackwell Munksgaard.
Keywords: controlled study; disease-free survival; leukemia; survival rate; transplantation, homologous; major clinical study; conference paper; follow-up studies; neoplasm recurrence, local; analytic method; genotype; risk factors; relapse; hematopoietic stem cell transplantation; confidence interval; homozygosity; hla matching; donor; hematologic neoplasms; hla-c antigens; ligands; killer cells, natural; living donors; killer cell immunoglobulin like receptor; hazard ratio; hla b antigen; hla c antigen; hla-b antigens; receptors, immunologic; nk; kir; natural killer
Journal Title: Tissue Antigens
Volume: 69
Issue: Suppl. 1
ISSN: 0001-2815
Publisher: Wiley-Blackwell Publishing, Inc.  
Date Published: 2007-04-01
Start Page: 42
End Page: 45
Language: English
DOI: 10.1111/j.1399-0039.2006.759_5.x
PUBMED: 17445161
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 10" - "Export Date: 17 November 2011" - "CODEN: TSANA" - "Source: Scopus"
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MSK Authors
  1. Katharine C Hsu
    152 Hsu
  2. Bo Dupont
    197 Dupont