Inhibitory killer Ig-like receptor genes and human leukocyte antigen class I ligands in haematopoietic stem cell transplantation Journal Article

  


Authors: Dupont, B.; Hsu, K. C.
Article Title: Inhibitory killer Ig-like receptor genes and human leukocyte antigen class I ligands in haematopoietic stem cell transplantation
Abstract: Identification of inhibitory killer Ig-like receptor (KIR) genes and their cognate human leukocyte antigen (HLA) class I ligands in donor-recipient pairs for patients undergoing haematopoietic stem cell transplantation (HCT) as treatment for haematopoietic malignancies has recently gained considerable interest. One incentive for these studies is to identify potential donors who are not HLA identical with the recipient but who still could serve as acceptable and potentially preferred donors based on their KIR genotype. It is demonstrated that a majority of individuals have at least one inhibitory KIR gene for which they lack the cognate HLA class I ligand. Therefore, the clinical benefits conferred by 'missing KIR ligand' might not be limited only to HLA mismatched donor-recipient combinations but may be applicable also to HLA identical transplants and even autologous HCT.
Keywords: gene cluster; review; nonhuman; genetic analysis; protein analysis; animals; gene; genetic variability; genotype; hematopoietic stem cell transplantation; immunoreactivity; genome analysis; hla matching; donor; molecular recognition; gene identification; hla antigen class 1; histocompatibility antigens class i; ligand; ligands; natural killer cell; killer cells, natural; malignant neoplastic disease; tumor immunity; inhibition kinetics; ethnic difference; cell activation; model; autologous hematopoietic stem cell transplantation; receptors, immunologic; phylogeny; patient; recipient; cell receptor; immunogenetics; immunobiology; humans; human
Journal Title: Current Opinion in Immunology
Volume: 16
Issue: 5
ISSN: 0952-7915
Publisher: Elsevier Inc.  
Date Published: 2004-10-01
Start Page: 634
End Page: 643
Language: English
DOI: 10.1016/j.coi.2004.07.013
PROVIDER: scopus
PUBMED: 15342011
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-4444307713&partnerID=40&md5=340a051c35328e8dc6998b08e5ed8050
Notes: Curr. Opin. Immunol. -- Cited By (since 1996):43 -- Export Date: 16 June 2014 -- CODEN: COPIE -- Source: Scopus
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MSK Authors
  1. Katharine C Hsu
    184 Hsu
  2. Bo Dupont
    264 Dupont
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