Synthetic studies with [(18)F]p‐fluorobenzenediazonium chloride: Application to the synthesis of a radiolabelled glucocorticoid: [(18)F]WIN 44577 Journal Article
| Author: | Feliu, A. L. |
| Article Title: | Synthetic studies with [(18)F]p‐fluorobenzenediazonium chloride: Application to the synthesis of a radiolabelled glucocorticoid: [(18)F]WIN 44577 |
| Abstract: | A, route was devised to synthesize no‐carrier‐added or carrier‐added [10F]p‐fluorophenylhydrazine from aqueous [18F]fluoride. Key reaction in this three‐step sequence is the reduction of [18F]p‐fluorobenzenediazonium chloride with sodium cyanoborohydride. The utility of this method is demonstrated by the synthesis of [10F]WIN 44577, an N‐(pfluorophenyl)pyrazole‐containing corticosteroid, which exhibits exceptionally high in vitro binding affinity for type‐II glucocorticoid receptors, and which is currently under evaluation as a possible radioligand for positron emission tomographic studies. Copyright © 1988 John Wiley & Sons, Ltd. |
| Keywords: | unclassified drug; nonhuman; glucocorticoid; radioisotope; synthesis; corticosteroids; diazonium salts; fluorine‐18; p‐fluoroaniline; p‐fluorophenylhydrazine; sodium cyanoborohydride; 4 fluorophenylhydrazine; win 44577 |
| Journal Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume: | 25 |
| Issue: | 11 |
| ISSN: | 0362-4803 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1988-11-01 |
| Start Page: | 1245 |
| End Page: | 1254 |
| Language: | English |
| DOI: | 10.1002/jlcr.2580251111 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
