| Abstract: |
Ascorbic acid is required for human physiology and is particularly important in maintaining normal connective tissue and host defense. Our interest in this carboxylic acid stems from its similarity in transport with glucose in human cells [1, 2]. In order to investigate these phenomena, we report a refined synthesis [3] of 6-[18F]-fluoro-6-deoxy-L-ascorbic acid (18F-FAA) via nucleophilic displacement of the cyclic sulfate with Kryptofix 2.2.2/K18F complex which results in multi-millicurie quantities of high specific activity product. The trace carrier-added synthesis has resulted in a decay corrected radiochemical yield of 31.6±3.4% with a specific activity approaching 180 mCi/μmol. Our preliminary experience with the assessment of the chemical stability of both the radiolabelled and stable product is also presented. |
