The synthesis of high radiochemical purity of 2‐[(18)F]‐fluoro‐2‐deoxy‐D‐glucose without the use of preparative HPLC Journal Article
| Authors: | Ginos, J. Z.; French, R.; Reamer, R. |
| Article Title: | The synthesis of high radiochemical purity of 2‐[(18)F]‐fluoro‐2‐deoxy‐D‐glucose without the use of preparative HPLC |
| Abstract: | A process is described for preparing routinely sterile and pyrogenfree, multimillicurie amounts of 2‐[18F]‐fluoro‐2‐deoxy‐D‐glucose (18F‐2FDG) with and without carrier‐added fluoride and with a radiochemical purity of greater than 98% without the use of preparative HPLC. For 13 consecutive runs, the radiochemical yield with carrier‐added fluoride was 35.5 ± 2.2%. The [18F]fluoride used was produced by the reaction 160(3He, p) 18F or by the reaction 180 (p,n)18F. Analytical HPLC, 1H and 19F NMR spectral analysis were used to establish the identity and purity of 18F‐2FDG. Copyright © 1987 John Wiley & Sons, Ltd. |
| Keywords: | high performance liquid chromatography; 2‐[18f]‐fluoro‐2‐deoxy‐d‐glucose; fluorine‐19 nuclear magnetic resonance |
| Journal Title: | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume: | 24 |
| Issue: | 7 |
| ISSN: | 0362-4803 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1987-07-01 |
| Start Page: | 805 |
| End Page: | 815 |
| Language: | English |
| DOI: | 10.1002/jlcr.2580240711 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
