A kinetic comparison of [(18)F]2-fluoro-2-deoxyglucose and [(18)F]2-fluoro-2-deoxymannose using positron emission tomography Journal Article
| Authors: | Braun, A. R.; Carson, R. E.; Adams, H. R.; Finn, R. D.; Francis, B. E.; Herscovitch, P. |
| Article Title: | A kinetic comparison of [(18)F]2-fluoro-2-deoxyglucose and [(18)F]2-fluoro-2-deoxymannose using positron emission tomography |
| Abstract: | Rate constants and fractional metabolic rates were estimated for the stereoisomers [18F]2-fiuoro-2-deoxyglucose (FDG) and [18F]2-fluoro-2-deoxymannose (FDM) in 5 male baboons using positron emission tomography. Each animal, serving as its own control, was injected with both compounds under controlled physiological conditions. Results indicate that there is a 20% reduction in apparent cerebral metabolic rates for glucose when FDM is used as the analogue. This suggests that as supplies of 18O become depleted, the presence of FDM as an impurity should warrant consideration in the choice of alternatives to no-carrier-added FDG synthesis. © 1994. |
| Keywords: | controlled study; nonhuman; comparative study; positron emission tomography; radiopharmaceuticals; animal; animals; animal experiment; animal model; central nervous system; kinetics; diagnostic agent; radiation dose fractionation; fluorodeoxyglucose f 18; computer assisted emission tomography; fluorodeoxyglucose f18; radiopharmaceutical agent; drug derivative; glucose blood level; blood glucose; radiochemistry; tomography, emission-computed; fluorine radioisotopes; glucose metabolism; fluorine; deoxyglucose; male; article; metabolic rate; baboon; papio; 2 deoxy 2 fluoromannose; 2-deoxy-2-fluoromannose; rhamnose; 2 deoxy 2 fluoromannose f 18 |
| Journal Title: | Nuclear Medicine and Biology |
| Volume: | 21 |
| Issue: | 6 |
| ISSN: | 0969-8051 |
| Publisher: | Elsevier Science Inc. |
| Date Published: | 1994-08-01 |
| Start Page: | 857 |
| End Page: | 863 |
| Language: | English |
| DOI: | 10.1016/0969-8051(94)90165-1 |
| PROVIDER: | scopus |
| PUBMED: | 9234335 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: NMBIE C2 -- Source: Scopus |
