Expression of human nerve growth factor receptor on cells derived from all three germ layers Journal Article
| Authors: | Thomson, T. M.; Rettig, W. J.; Garin Chesa, P.; Green, S. H.; Carrato Mena, A.; Old, L. J. |
| Article Title: | Expression of human nerve growth factor receptor on cells derived from all three germ layers |
| Abstract: | Nerve growth factor (NGF) is a protein which promotes the survival and differentiation of neuronal cells in vitro and plays an important role in neuronal development. In this study, we have examined the expression of the receptor for NGF (NGFR) in human neuronal and nonneuronal cells, both in tissue culture and in vivo. In addition to cell lines derived from neuroblastoma, astrocytoma, and melanoma, all of which share a common neuroectodermal origin, NGFR was detected in a number of cultured cells of mesenchymal, epithelial, and hematopoietic derivation. Immunohistochemical analysis showed that NGFR is expressed in several nonneural human tissues, and the cell types in which NGFR was found include derivatives from all three germ layers. Thus, our findings demonstrate that NGFR is much more widely expressed in human cells and tissues than was previously thought. © 1988. |
| Keywords: | immunohistochemistry; controlled study; human cell; flow cytometry; cytology; cell survival; cells, cultured; cell differentiation; nerve growth factors; neurons; tumor cells, cultured; fluorescent antibody technique; cell culture; neuroblastoma cell; melanoma cell; receptors, cell surface; nerve growth factor receptor; receptors, nerve growth factor; germ layer; nerve growth factor; astrocytoma cell; human; hemadsorption; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Experimental Cell Research |
| Volume: | 174 |
| Issue: | 2 |
| ISSN: | 0014-4827 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1988-02-01 |
| Start Page: | 533 |
| End Page: | 539 |
| Language: | English |
| DOI: | 10.1016/0014-4827(88)90323-0 |
| PUBMED: | 2828087 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 6 August 2020 -- Source: Scopus |
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