Immunohistochemical analysis of nerve growth factor receptor expression in normal and malignant human tissues Journal Article

  


Authors: Chesa, P. G.; Rettig, W. J.; Thomson, T. M.; Old, L. J.; Melamed, M. R.
Article Title: Immunohistochemical analysis of nerve growth factor receptor expression in normal and malignant human tissues
Abstract: Nerve growth factor (NGF) is a polypeptide important for normal development of the nervous system and promotion of survival and differentiation of sensory and sympathetic neurons in culture. The cellular effects of NGF are mediated by a specific cell surface molecule, nerve growth factor receptor (NGF-R). In the present study we have used a monoclonal antibody against human NGF-R to examine, by the avidin-biotin-immunoperoxidase method, the receptor distribution in a wide range of normal tissues and in more than 200 malignant tumors. Our results show that (a) human NGF-R is expressed in the peripheral nervous system but not in any of the central nervous system areas tested; (b) NGF-R expression is not restricted to neural tissues but is also found in a number of normal epithelial, mesenchymal, and lymphoid tissues; (c) NGF-R expression changes during normal development; and (d) NGF-R expression in malignant tumors generally parallels its normal tissue distribution. Thus, NGF-R is detected in a proportion of neuroectoderm-derived tumors, carcinomas, and lymphomas, and also in a characteristic group of small round-cell tumors (Ewing's sarcomas and embryonal rhabdomyosarcomas). These findings suggest a normal regulatory role for NGF in both neuronal and non-neuronal cells and identify a range of human tumors in which the NGF/NGF-R system may contribute to the malignant phenotype.
Keywords: human cell; monoclonal antibody; ewing sarcoma; histochemistry; rhabdomyosarcoma; etiology; nerve growth factor receptor; nerve growth factor; human
Journal Title: Journal of Histochemistry and Cytochemistry
Volume: 36
Issue: 4
ISSN: 0022-1554
Publisher: Sage Publications  
Date Published: 1988-04-01
Start Page: 383
End Page: 389
Language: English
DOI: 10.1177/36.4.2831267
PUBMED: 2831267
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023933194&doi=10.1177%2f36.4.2831267&partnerID=40&md5=362638d470e868a8d5b0ec5efc03b5fc
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Lloyd J Old
    593 Old
  2. Pilar Garin-Chesa
    73 Garin-Chesa
  3. Wolfgang J. Rettig
    85 Rettig
  4. Myron Melamed
    148 Melamed
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