Congenital chromosome breakage clusters within giemsa-light bands and identifies sites of chromatin instability Journal Article

  


Authors: Koduru, P.; Chaganti, R.
Article Title: Congenital chromosome breakage clusters within giemsa-light bands and identifies sites of chromatin instability
Abstract: Analysis of the distribution of published chromosome breaks in cells with constitutional chromosome aberrations showed a Non-random distribution of breaks among chromosomes and chromosome regions. A significant amount of breakage occurred at Giemsa-negative bands. In addition, chromosome sites associated with a number of fragile sites and cellular oncogene sites were affected Non-randomly. The data are consistent with the hypothesis that chromosome breakage occurs in somatic or germ cells as a result of recombinational errors involving actively transcribing chromatin regions or regions of unstable DNA sequence structure placed in proximity during interphase. © 1988 S. Karger AG, Basel.
Keywords: review; cytology; heredity; genetic transcription; genetic recombination; chromatin; chromosome breakage; dna structure; chromosome aberrations; karyotyping; genetic markers; chromatin structure; proto-oncogenes; chromosome g band; chromosome banding; chromosome fragility; human; support, u.s. gov't, p.h.s.; azure stains
Journal Title: Cytogenetics and Cell Genetics
Volume: 49
Issue: 4
ISSN: 0301-0171
Publisher: S. Karger AG  
Date Published: 1988-01-01
Start Page: 269
End Page: 274
Language: English
DOI: 10.1159/000132675
PUBMED: 3248384
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024155029&doi=10.1159%2f000132675&partnerID=40&md5=e21c01b2a82dda287add5ac11bb6f4d5
Notes: Article -- Export Date: 6 August 2020 -- Source: Scopus
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MSK Authors
  1. Raju S K Chaganti
    391 Chaganti
  2. Prasad R. K. Koduru
    17 Koduru
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