Nonrandom chromosomal aberrations are associated with sites of tissue involvement in non-Hodgkin's lymphoma Journal Article

  


Authors: Offit, K.; Richardson, M. E.; Quanguang, C.; Hampton, A.; Koduru, P. R. K.; Jhanwar, S. C.; Filippa, D. A.; Lieberman, P. H.; Clarkson, B.; Chaganti, R. S. K.
Article Title: Nonrandom chromosomal aberrations are associated with sites of tissue involvement in non-Hodgkin's lymphoma
Abstract: In an effort to assess the utility of pretreatment cytogenetics as indicators of sites of involvement by lymphoma, clinical and cytogenetic correlations were performed on 133 consecutive specimens derived from 130 patients with non-Hodgkin's lymphoma. Nonrandom chromosomal aberrations detected at the time of diagnosis were associated with sites of clinical involvement presenting initially or during the progression of the lymphoma. Statistically significant associations included translocation breaks involving the chromosomal region 1p32-36 and bone marrow involvement, chromosome 14 abnormalities including breaks at 14q22-24 and splenic involvement, chromosome 9 abnormalities and pulmonary involvement, and monosomy 11 and bone involvement. A significant correlation was also observed between breaks involving the region 6q22-24, detected during the course of disease, and bone marrow involvement by lymphoma. The relationship of the sites of nonrandom chromosomal breakage reported here to known cellular oncogenes and implications to concepts of tumor evolution and spread are discussed. © 1989.
Keywords: major clinical study; cytology; heredity; bone marrow; spleen; chromosome aberration; oncogene; nonhodgkin lymphoma; lymphoma, non-hodgkin; lung; chromosome breakage; bone and bones; chromosome aberrations; karyotyping; human; priority journal; support, u.s. gov't, p.h.s.
Journal Title: Cancer Genetics and Cytogenetics
Volume: 37
Issue: 1
ISSN: 0165-4608
Publisher: Elsevier Science, Inc.  
Date Published: 1989-01-01
Start Page: 85
End Page: 93
Language: English
DOI: 10.1016/0165-4608(89)90078-2
PUBMED: 2917335
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024593619&doi=10.1016%2f0165-4608%2889%2990078-2&partnerID=40&md5=51361dcf8aabd0b3d4260e5fa14a4840
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Kenneth Offit
    788 Offit
  2. Daniel A Filippa
    148 Filippa
  3. Raju S K Chaganti
    391 Chaganti
  4. Suresh C Jhanwar
    293 Jhanwar
  5. Bayard Clarkson
    220 Clarkson
  6. Philip H Lieberman
    42 Lieberman
  7. Prasad R. K. Koduru
    17 Koduru
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