Clusters of chromosome 9 aberrations are associated with clinico‐pathologic subsets of non‐Hodgkin's lymphoma Journal Article
| Authors: | Offit, K.; Parsa, N. Z.; Jhanwar, S. C.; Filippa, D.; Wachtel, M.; Chaganti, R. S. K. |
| Article Title: | Clusters of chromosome 9 aberrations are associated with clinico‐pathologic subsets of non‐Hodgkin's lymphoma |
| Abstract: | In this study we analyzed nonrandom aberrations affecting chromosome 9 in a series of 426 consecutively ascertained, karyotypically abnormal non‐Hodgkin's lymphoma (NHL) tumors derived from 407 patients. Cytogenetic abnormalities were correlated with clinical, histologic, and immunologic features. Structural abnormalities of chromosome 9 were identified in 60 specimens derived from 59 patients. The recurring abnormalities among these were associated with 4 clinico‐pathologic subsets. The first comprised 7 cases of t(9;14)(p13;q32), 6 of which had small lymphocytic lymphoma, plasmacytoid subtype, and an indolent clinical course. The second group included 12 cases with breaks at 9q11–13 and diffuse lymphomas with a large‐cell component and a typical response to combination chemotherapy. The third group was comprised of 7 cases with 9q deletions, with a common deleted region encompassing 9q31–32. These cases were characterized by diffuse B‐cell histology, young age, and poor clinical outcome. The fourth subset included 5 intermediate‐ to high‐grade T‐cell tumors with breaks at 9q34. This analysis of chromosome 9 aberrations in NHL comprises the first such effort based on a large series of tumors. We identify and report here new clinico‐pathologic subsets with shared abnormalities of chromosome 9, which should facilitate new approaches to the analysis of the etiology and clinical behavior of NHL. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | human tissue; major clinical study; in situ hybridization, fluorescence; chromosomes, human, pair 9; cytogenetics; biopsy; chromosome aberration; nonhodgkin lymphoma; gene rearrangement; lymphoma, non-hodgkin; chromosome aberrations; chromosome deletion; karyotyping; chromosome 9; chromosomes, human, pair 12; chromosome disorders; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translocation (genetics) |
| Journal Title: | Genes Chromosomes and Cancer |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 1045-2257 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 1993-05-01 |
| Start Page: | 1 |
| End Page: | 7 |
| Language: | English |
| DOI: | 10.1002/gcc.2870070102 |
| PUBMED: | 7688550 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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