Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: Clinical correlations Journal Article
| Authors: | Offit, K.; Wong, G.; Filippa, D. A.; Tao, Y.; Chaganti, R. S. K. |
| Article Title: | Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: Clinical correlations |
| Abstract: | Cytogenetic and histopathologic data were correlated with clinical parameters from 423 patients with non-Hodgkin's lymphoma (NHL). Clinical correlations were performed on subgroups of 149 patients with low-grade lymphoma (LG) and 205 patients with diffuse lymphoma with a large cell component (DLLC). Correlations were made between clinical outcome and individual recurring cytogenetic aberrations, each of which was noted in >5% of cases belonging to LG NHL and DLLC, and derived measures of karyotypic complexity, comprising modal chromosome number, number of marker chromosomes, and number of translocation break-points. No correlations with survival were noted in LG NHL, although median follow-up was only 2 years. Seven patients with t(8;14) LG NHL had an indolent course. Among 104 patients with DLLC and abnormal karyotypes at diagnosis, breaks at 1q21-23 or more than 4 marker chromosomes was associated with a shortened median survival. Using these variables we constructed a proportional hazards model with a good fit to observed data. Breaks at 6q21-25 predicted a decreased probability of achieving remission. Patients with DLLC and breaks at 1q21-23 or 1p32-36 had a shorter duration of complete remission. Of 41 DLLC studied at relapse, the only long-term survivors had t(14;18). |
| Keywords: | adult; controlled study; aged; human cell; major clinical study; follow-up studies; neoplasm staging; cytogenetics; nonhodgkin lymphoma; lymphoma, non-hodgkin; chromosome aberrations; analysis of variance; karyotyping; genetic markers; trisomy; prognosis; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translocation (genetics) |
| Journal Title: | Blood |
| Volume: | 77 |
| Issue: | 7 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 1991-04-01 |
| Start Page: | 1508 |
| End Page: | 1515 |
| Language: | English |
| PUBMED: | 2009370 |
| PROVIDER: | scopus |
| DOI: | 10.1182/blood.V77.7.1508.1508 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work