Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical carcinoma Journal Article
| Authors: | De Braekeleer, M.; Sreekantaiah, C.; Haas, O. |
| Article Title: | Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical carcinoma |
| Abstract: | The distribution of 1,912 breakpoints observed in a series of 148 cervical cancers was analyzed. Fifty bands were shown to be nonrandomly involved in chromosome structural rearrangements. One hundred thirty-three breaks were noted in bands known to contain a human papillomavirus integration site, and 454 breaks were noted in bands containing a herpes simplex virus breakage site. We suggest that herpes simplex viruses and, possibly, papillomaviruses play an important role in the carcinogenesis and/or development of cytogenetic abnormalities in cervical cancers. © 1992. |
| Keywords: | human cell; major clinical study; carcinogenesis; simplexvirus; chromosome breakage; chromosome aberrations; herpes simplex virus; herpes; uterine cervix carcinoma; wart virus; human papillomavirus; cervix neoplasms; chromosome banding; virus integration; papillomavirus; chromosome band; chromosome fragility; human; female; priority journal; article; support, non-u.s. gov't; human papillomavirus types |
| Journal Title: | Cancer Genetics and Cytogenetics |
| Volume: | 59 |
| Issue: | 2 |
| ISSN: | 0165-4608 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1992-04-01 |
| Start Page: | 135 |
| End Page: | 137 |
| Language: | English |
| DOI: | 10.1016/0165-4608(92)90207-o |
| PUBMED: | 1316222 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 30 July 2019 -- Source: Scopus |
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