CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: A practical overview Review

  


Authors: Mohty, M.; Dulery, R.; Gauthier, J.; Malard, F.; Brissot, E.; Aljurf, M.; Bazarbachi, A.; Chabanon, C.; Kharfan-Dabaja, M. A.; Savani, B. N.; Huang, H.; Kenderian, S. S.; Perales, M. A.; Yakoub-Agha, I.; Nagler, A.
Review Title: CAR T-cell therapy for the management of refractory/relapsed high-grade B-cell lymphoma: A practical overview
Abstract: The goal of this review is to firstly address the concept of chimeric antigen receptor T-cell (CAR T-cell) therapy and where it fits in the evolving landscape of the management of patients with refractory/relapsed diffuse large B-cell lymphoma. The recognition of the indications for CAR T-cell therapy for patients with aggressive B-cell lymphoma will be discussed, including a review of the algorithms and selection criteria for CAR T-cell therapy and finally, the role of bridging therapy and the timing of CAR T-cell therapy in augmenting chances of a successful outcome. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.
Keywords: cancer chemotherapy; cancer survival; protein expression; review; cancer recurrence; salvage therapy; patient selection; cancer patient; neurotoxicity; cancer grading; treatment indication; tumor lysis syndrome; patient care; b cell lymphoma; cancer regression; patient safety; chimeric antigen receptor; clinical effectiveness; t cell depletion; immunoglobulin deficiency; cytopenia; t lymphocyte activation; opportunistic infection; disease activity; clinical outcome; diffuse large b cell lymphoma; aplasia; human; priority journal; tisagenlecleucel t; chimeric antigen receptor t-cell immunotherapy; axicabtagene ciloleucel; lisocabtagene maraleucel; lisocel
Journal Title: Bone Marrow Transplantation
Volume: 55
Issue: 8
ISSN: 0268-3369
Publisher: Nature Publishing Group  
Date Published: 2020-08-01
Start Page: 1525
End Page: 1532
Language: English
DOI: 10.1038/s41409-020-0892-7
PUBMED: 32305998
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083883799&doi=10.1038%2fs41409-020-0892-7&partnerID=40&md5=0b621e1107e23651b94c631737d70857
Notes: Review -- Source: Scopus
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  1. Miguel-Angel Perales
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