NCCN Guidelines® Insights: B-cell lymphomas, version 6.2023 Guidelines


Authors: Zelenetz, A. D.; Gordon, L. I.; Abramson, J. S.; Advani, R. H.; Andreadis, B.; Bartlett, N. L.; Budde, L. E.; Caimi, P. F.; Chang, J. E.; Christian, B.; DeVos, S.; Dholaria, B.; Fayad, L. E.; Habermann, T. M.; Hamid, M. S.; Hernandez-Ilizaliturri, F.; Hu, B.; Kaminski, M. S.; Karimi, Y.; Kelsey, C. R.; King, R.; Krivacic, S.; LaCasce, A. S.; Lim, M.; Messmer, M.; Narkhede, M.; Rabinovitch, R.; Ramakrishnan, P.; Reid, E.; Roberts, K. B.; Saeed, H.; Smith, S. D.; Svoboda, J.; Swinnen, L. J.; Tuscano, J.; Vose, J. M.; Dwyer, M. A.; Sundar, H.
Title: NCCN Guidelines® Insights: B-cell lymphomas, version 6.2023
Abstract: Novel targeted therapies (small molecule inhibitors, antibody-drug conjugates, and CD19-directed therapies) have changed the treatment landscape of relapsed/refractory B-cell lymphomas. Bruton's tyrosine kinase (BTK) inhibitors continue to evolve in the management of mantle cell lymphoma (MCL), in both the relapsed/refractory and the frontline setting. Anti-CD19 CAR T-cell therapies are now effective and approved treatment options for relapsed/refractory follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), and MCL. Bispecific T-cell engagers represent a novel immunotherapeutic approach for relapsed FL and DLBCL after multiple lines of therapies, including prior CAR T-cell therapy. These NCCN Guideline Insights highlight the significant updates to the NCCN Guidelines for B-Cell Lymphomas for the treatment of FL, DLBCL, and MCL.
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 21
Issue: 11
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2023-11-01
Start Page: 1118
End Page: 1131
Language: English
DOI: 10.6004/jnccn.2023.0057
PUBMED: 37935098
PROVIDER: scopus
DOI/URL:
Notes: Article -- Source: Scopus
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  1. Andrew D Zelenetz
    767 Zelenetz
  2. Megan So-Young Lim
    25 Lim