Emerging role of CAR T cells in non-Hodgkin's lymphoma Journal Article

  


Authors: Avanzi, M. P.; Brentjens, R. J.
Article Title: Emerging role of CAR T cells in non-Hodgkin's lymphoma
Abstract: Adoptive T-cell therapy with chimeric antigen receptor T cells (CAR-Ts) has produced impressive clinical responses among patients with B-cell malignancies, and several groups have published positive results using anti-CD19 CAR-Ts for the treatment of B-cell acute lymphoblastic leukemia. Recently, new data from clinical trials have demonstrated the benefits of CAR-T therapy in the non-Hodgkin's lymphoma (NHL) setting. This review describes some of the most recent and promising advances in engineered T-cell therapy, with particular emphasis on the clinical benefits of NHL treatment. © JNCCN - Journal of the National Comprehensive Cancer Network.
Keywords: cancer chemotherapy; review; nonhuman; neurotoxicity; t lymphocyte; cancer immunotherapy; progression free survival; hematopoietic stem cell transplantation; cell lineage; hypoxia; acute kidney failure; hypotension; cd20 antigen; t cell lymphoma; nonhodgkin lymphoma; chimeric antigen receptor; large cell lymphoma; cd5 antigen; adoptive immunotherapy; cd19 antigen; cd22 antigen; cd137 antigen; human
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 15
Issue: 11
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2017-11-01
Start Page: 1429
End Page: 1437
Language: English
DOI: 10.6004/jnccn.2017.7045
PROVIDER: scopus
PUBMED: 29118234
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033778744&doi=10.6004%2fjnccn.2017.7045&partnerID=40&md5=5b3cc1af705d1de57e50a8939eb667f1
Notes: Review -- Export Date: 2 January 2018 -- Source: Scopus
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MSK Authors
  1. Renier J Brentjens
    286 Brentjens
  2. Mauro Pellegrino Avanzi
    3 Avanzi
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