CAR therapy for hematological cancers: Can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies? Journal Article
| Authors: | Pegram, H. J.; Smith, E. L.; Rafiq, S.; Brentjens, R. J. |
| Article Title: | CAR therapy for hematological cancers: Can success seen in the treatment of B-cell acute lymphoblastic leukemia be applied to other hematological malignancies? |
| Abstract: | Chimeric antigen receptor (CAR) T-cell therapy has recently come into the spotlight due to impressive results in patients with B-cell acute lymphoblastic leukemia. By targeting CD19, a marker expressed most B-cell tumors, as well as normal B cells, CAR T-cell therapy has been investigated as a treatment strategy for B-cell leukemia and lymphoma. This review will discuss the successes of this therapy for the treatment of B-cell acute lymphoblastic leukemia and the challenges to this therapeutic strategy. We will also discuss application of CAR T-cell therapy to chronic lymphocytic leukemia and other B-cell malignancies including a follicular lymphoma, diffuse large B-cell lymphoma, as well as acute and plasma cell malignancies. © 2015 Future Medicine Ltd. |
| Keywords: | t cells; immunotherapy; chimeric antigen receptor; car; autologous t-cell infusion; b-cell malignancies |
| Journal Title: | Immunotherapy |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 1750-743X |
| Publisher: | Future Medicine |
| Date Published: | 2015-01-01 |
| Start Page: | 545 |
| End Page: | 561 |
| Language: | English |
| DOI: | 10.2217/imt.15.6 |
| PROVIDER: | scopus |
| PUBMED: | 26065479 |
| PMCID: | PMC5238709 |
| DOI/URL: | |
| Notes: | Export Date: 2 July 2015 -- Source: Scopus |
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