TMPRSS2 and COVID-19: Serendipity or opportunity for intervention? Editorial

   


Authors: Stopsack, K. H.; Mucci, L. A.; Antonarakis, E. S.; Nelson, P. S.; Kantoff, P. W.
Title: TMPRSS2 and COVID-19: Serendipity or opportunity for intervention?
Abstract: TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections. © 2020 American Association for Cancer Research.
Keywords: genetics; mortality; genetic predisposition to disease; drug effect; pathology; prostatic neoplasms; gene expression regulation; serine proteinase; serine endopeptidases; prostate tumor; serine proteinase inhibitor; genetic predisposition; influenza; virus pneumonia; influenza, human; serine proteinase inhibitors; pandemic; pneumonia, viral; humans; human; male; female; coronavirus infections; betacoronavirus; coronavirus infection; pandemics; camostat; gabexate; tmprss2 protein, human
Journal Title: Cancer Discovery
Volume: 10
Issue: 6
ISSN: 2159-8274
Publisher: American Association for Cancer Research  
Date Published: 2020-06-01
Start Page: 779
End Page: 782
Language: English
DOI: 10.1158/2159-8290.Cd-20-0451
PUBMED: 32276929
PROVIDER: scopus
PMCID: PMC7437472
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083856342&doi=10.1158%2f2159-8290.CD-20-0451&partnerID=40&md5=a346d9b1145d932cdb65ef724caf4464
Notes: Article -- Export Date: 1 July 2020 -- Source: Scopus
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MSK Authors
  1. Philip Wayne Kantoff
    197 Kantoff
  2. Konrad Hermann Stopsack
    69 Stopsack
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