Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis Journal Article
| Authors: | King, J. C.; Xu, J.; Wongvipat, J.; Hieronymus, H.; Carver, B. S.; Leung, D. H.; Taylor, B. S.; Sander, C.; Cardiff, R. D.; Couto, S. S.; Gerald, W. L.; Sawyers, C. L. |
| Article Title: | Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis |
| Abstract: | The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis. © 2009 Nature America, Inc. All rights reserved. |
| Keywords: | signal transduction; controlled study; unclassified drug; disease course; nonhuman; mouse; animals; mice; animal tissue; mus; animal experiment; animal model; enzyme activation; carcinogenesis; mice, transgenic; prostate cancer; prostatic neoplasms; prostate; 1-phosphatidylinositol 3-kinase; transcription factor erg; fusion gene; oncogene proteins, fusion; rna translation; binding site; prostatic intraepithelial neoplasia; phosphotransferase; p13 kinase; tmprss2 transcription factor erg |
| Journal Title: | Nature Genetics |
| Volume: | 41 |
| Issue: | 5 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-05-01 |
| Start Page: | 524 |
| End Page: | 526 |
| Language: | English |
| DOI: | 10.1038/ng.371 |
| PUBMED: | 19396167 |
| PROVIDER: | scopus |
| PMCID: | PMC2898503 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 35" - "Export Date: 30 November 2010" - "CODEN: NGENE" - "Source: Scopus" |
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