Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis Journal Article


Authors: King, J. C.; Xu, J.; Wongvipat, J.; Hieronymus, H.; Carver, B. S.; Leung, D. H.; Taylor, B. S.; Sander, C.; Cardiff, R. D.; Couto, S. S.; Gerald, W. L.; Sawyers, C. L.
Article Title: Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
Abstract: The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis. © 2009 Nature America, Inc. All rights reserved.
Keywords: signal transduction; controlled study; unclassified drug; disease course; nonhuman; mouse; animals; mice; animal tissue; mus; animal experiment; animal model; enzyme activation; carcinogenesis; mice, transgenic; prostate cancer; prostatic neoplasms; prostate; 1-phosphatidylinositol 3-kinase; transcription factor erg; fusion gene; oncogene proteins, fusion; rna translation; binding site; prostatic intraepithelial neoplasia; phosphotransferase; p13 kinase; tmprss2 transcription factor erg
Journal Title: Nature Genetics
Volume: 41
Issue: 5
ISSN: 1061-4036
Publisher: Nature Publishing Group  
Date Published: 2009-05-01
Start Page: 524
End Page: 526
Language: English
DOI: 10.1038/ng.371
PUBMED: 19396167
PROVIDER: scopus
PMCID: PMC2898503
DOI/URL:
Notes: --- - "Cited By (since 1996): 35" - "Export Date: 30 November 2010" - "CODEN: NGENE" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Charles L Sawyers
    157 Sawyers
  2. Jennifer King
    3 King
  3. William L Gerald
    370 Gerald
  4. Jin Xu
    3 Xu
  5. Brett Stewart Carver
    109 Carver
  6. Chris Sander
    196 Sander
  7. Barry Stephen Taylor
    144 Taylor
  8. David H Leung
    3 Leung