A prospective study of aspirin use and prostate cancer risk by TMPRSS2:ERG status Journal Article

Authors: Stopsack, K. H.; Gonzalez-Feliciano, A. G.; Peisch, S. F.; Downer, M. K.; Gage, R. A.; Finn, S.; Lis, R. T.; Graff, R. E.; Pettersson, A.; Pernar, C. H.; Loda, M.; Kantoff, P. W.; Ahearn, T. U.; Mucci, L. A.; behalf of the Transdisciplinary Prostate Cancer Partnership (ToPCaP)
Article Title: A prospective study of aspirin use and prostate cancer risk by TMPRSS2:ERG status
Abstract: Background: In a case-control study, aspirin use was associated with a lower risk of a common prostate cancer molecular subtype, the TMPRSS2:ERG gene fusion. We sought to validate this finding in a prospective cohort. Methods: In the Health Professionals Follow-up Study, 49,395 men reported on aspirin use on biennial questionnaires and were followed for prostate cancer incidence over 23 years. TMPRSS2:ERG status was assessed by IHC for presence of ERG on archival tumor specimens for 912 patients with prostate cancer, of whom 48% were ERGpositive. Results: In multivariable models, we found no association between regular use of aspirin and risk of ERG-positive prostate cancer (HR, 1.02; 95% confidence interval, 0.85-1.23), nor any association with duration or frequency of aspirin use. In restricting to cases with either high Gleason grade or advanced stage disease, there remained no association with aspirin use. Conclusions: Data from this prospective study with repeated assessments of aspirin use do not support the hypothesis that aspirin use is associated with a lower risk of ERG-positive prostate cancer. Impact: Aspirin use is unlikely to lower the risk of this common molecular subtype of prostate cancer. However, there is emerging data supporting the role of other lifestyle and genetic factors underlying the development of the TMPRSS2:ERG fusion. © 2018 American Association for Cancer Research.
Journal Title: Cancer Epidemiology Biomarkers and Prevention
Volume: 27
Issue: 10
ISSN: 1055-9965
Publisher: American Association for Cancer Research  
Date Published: 2018-10-01
Start Page: 1231
End Page: 1233
Language: English
DOI: 10.1158/1055-9965.epi-18-0510
PUBMED: 30108097
PROVIDER: scopus
PMCID: PMC6170677
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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  1. Philip Wayne Kantoff
    62 Kantoff