The present and future of optical imaging technologies in the clinic: Diagnosis and therapy Journal Article


Authors: Stater, E. P.; Skubal, M.; Tamura, R.; Grimm, J.
Article Title: The present and future of optical imaging technologies in the clinic: Diagnosis and therapy
Abstract: Medical techniques based upon optical imaging technologies are important tools in clinical practice. The use of optical imaging in medical diagnosis is well established, and a large array of techniques are in current use, such as white light endoscopy, autofluorescence imaging, and optical coherence tomography. The applications of these techniques are expanding, and newer imaging technologies are becoming available to address problems and limitations associated with existing methods. Beyond diagnostics, optical imaging is increasingly a useful component of interventional medical procedures, such as image-guided surgery. In procedures such as surgical tumor resection, fluorescence imaging can aid surgeons in improving both accuracy and completeness of removal. Relevant to both diagnostic and therapeutic applications, Cerenkov luminescence imaging is a potential clinical technique which relies upon generation of visible-spectrum light by beta particles in a dielectric medium; this method could allow for coupling of a multimodal optical component to existing molecular imaging techniques, such as positron emission tomography, and also provide a means of monitoring distribution of administered clinically relevant radionuclides such as lutetium-177. © 2019, Springer Nature Switzerland AG.
Keywords: cancer surgery; positron emission tomography; clinical practice; diagnostic procedure; molecular imaging; diagnostic imaging; drug distribution; colonoscopy; clinical effectiveness; endoscopy; clinical imaging; gastroscopy; therapy; fluorescence imaging; electron; optical coherence tomography; narrow band imaging; white light endoscopy; cerenkov luminescence imaging; raman spectrometry; lutetium 177; priority journal; autofluorescence imaging; intraoperative imaging; interferometry; confocal laser scanning microscopy; two photon endomicroscopy
Journal Title: Topics in Medicinal Chemistry
Volume: 34
ISSN: 1862-2461
Publisher: Springer Nature Switzerland Ag  
Date Published: 2020-01-01
Start Page: 203
End Page: 223
Language: English
DOI: 10.1007/7355_2019_84
PROVIDER: scopus
DOI/URL:
Notes: Chapter in "Fluorescent Imaging in Medicinal Chemistry" (ISBN: 978-3-030-46706-7) -- Export Date: 1 July 2020 -- Source: Scopus
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MSK Authors
  1. Jan Grimm
    61 Grimm
  2. Ryo Tamura
    3 Tamura
  3. Magdalena Skubal
    2 Skubal