Near-infrared intraoperative chemiluminescence imaging Journal Article


Authors: Büchel, G. E.; Carney, B.; Shaffer, T. M.; Tang, J.; Austin, C.; Arora, M.; Zeglis, B. M.; Grimm, J.; Eppinger, J.; Reiner, T.
Article Title: Near-infrared intraoperative chemiluminescence imaging
Abstract: Intraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near-infrared light upon exposure to an aqueous solution of Ce4+ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9 pmol cm−2 of the transition-metal-based ICI agent. As a proof of concept, we use ICI for the in vivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal-to-noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords: intraoperative imaging; chemiluminescence; ruthenium; lymph node imaging; near infrared
Journal Title: ChemMedChem
Volume: 11
Issue: 18
ISSN: 1860-7179
Publisher: Wiley Blackwell  
Date Published: 2016-09-20
Start Page: 1978
End Page: 1982
Language: English
DOI: 10.1002/cmdc.201600301
PUBMED: 27471800
PROVIDER: scopus
PMCID: PMC5061038
DOI/URL:
Notes: Article -- Export Date: 3 October 2016 -- Source: Scopus
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MSK Authors
  1. Jan Grimm
    62 Grimm
  2. Brian Zeglis
    79 Zeglis
  3. Travis Michael Shaffer
    14 Shaffer
  4. Thomas Reiner
    103 Reiner
  5. Jun   Tang
    19 Tang
  6. Brandon Daniel Carney
    20 Carney
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