Near-infrared intraoperative chemiluminescence imaging Journal Article
| Authors: | Büchel, G. E.; Carney, B.; Shaffer, T. M.; Tang, J.; Austin, C.; Arora, M.; Zeglis, B. M.; Grimm, J.; Eppinger, J.; Reiner, T. |
| Article Title: | Near-infrared intraoperative chemiluminescence imaging |
| Abstract: | Intraoperative imaging technologies recently entered the operating room, and their implementation is revolutionizing how physicians plan, monitor, and perform surgical interventions. In this work, we present a novel surgical imaging reporter system: intraoperative chemiluminescence imaging (ICI). To this end, we have leveraged the ability of a chemiluminescent metal complex to generate near-infrared light upon exposure to an aqueous solution of Ce4+ in the presence of reducing tissue or blood components. An optical camera spatially resolves the resulting photon flux. We describe the construction and application of a prototype imaging setup, which achieves a detection limit as low as 6.9 pmol cm−2 of the transition-metal-based ICI agent. As a proof of concept, we use ICI for the in vivo detection of our transition metal tracer following both systemic and subdermal injections. The very high signal-to-noise ratios make ICI an interesting candidate for the development of new intraoperative imaging technologies. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| Keywords: | intraoperative imaging; chemiluminescence; ruthenium; lymph node imaging; near infrared |
| Journal Title: | ChemMedChem |
| Volume: | 11 |
| Issue: | 18 |
| ISSN: | 1860-7179 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2016-09-20 |
| Start Page: | 1978 |
| End Page: | 1982 |
| Language: | English |
| DOI: | 10.1002/cmdc.201600301 |
| PUBMED: | 27471800 |
| PROVIDER: | scopus |
| PMCID: | PMC5061038 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2016 -- Source: Scopus |
Altmetric
Citation Impact
Related MSK Work