The time course of steroid action on blood‐to‐brain and blood‐to‐tumor transport of (82)Rb: A positron emission tomographic study Journal Article

  


Authors: Jarden, J. O.; Dhawan, V.; Moeller, J. R.; Strother, S. C.; Rottenberg, D. A.
Article Title: The time course of steroid action on blood‐to‐brain and blood‐to‐tumor transport of (82)Rb: A positron emission tomographic study
Abstract: Blood‐to‐brain and blood‐to‐tumor transport rate constants for Rb (K1) and apparent tissue blood volume (Vb) were estimated in 8 patients with primary or metastatic brain tumors before and approximately 6 hours after a 100‐mg intravenous bolus injection of dexamethasone using 82Rb and positron emission tomography. Eight additional patients were studied to evaluate test‐retest variability and repositioning errors. Six hours following dexamethasone administration tumor K1 (but not Vb) was significantly reduced compared with contralateral control brain regions (p < 0.03). These data are consistent with our previously published 24‐hour‐postdexamethasone data and suggest that comparable effects of corticosteroids on brain/tumor capillaries may be observed at 5 to 6 and 24 hours. The time course of dexamethasone‐induced alterations in brain/tumor capillary permeability supports the view that these alterations may be responsible for at least some of the antiedema effects of corticosteroids. Copyright © 1989 The American Neurological Association
Keywords: adolescent; adult; clinical article; positron emission tomography; glioma; brain neoplasms; antineoplastic agent; dexamethasone; diagnosis; blood brain barrier; blood-brain barrier; brain metastasis; radioisotope; intravenous drug administration; brain edema; tomography, emission-computed; computer analysis; middle age; rubidium; human; male; female; priority journal; support, u.s. gov't, p.h.s.; rubidium radioisotopes
Journal Title: Annals of Neurology
Volume: 25
Issue: 3
ISSN: 0364-5134
Publisher: Wiley Blackwell  
Date Published: 1989-03-01
Start Page: 239
End Page: 245
Language: English
DOI: 10.1002/ana.410250306
PUBMED: 2786367
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024600353&doi=10.1002%2fana.410250306&partnerID=40&md5=680dfdd78c7956c251e07b0eb68f19a9
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. David A. Rottenberg
    41 Rottenberg
  2. Stephen C. Strother
    24 Strother
  3. Vijay Dhawan
    22 Dhawan
  4. James Moeller
    17 Moeller
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