Positron emission tomographic measurement of blood-to-brain and blood-to-tumour transport of (82)Rb. II: Clinical data and validation of technique Journal Article

  


Authors: Dhawan, V.; Jarden, J. O.; Moeller, J. R.; Strother, S. C.; Rottenberg, D. A.
Article Title: Positron emission tomographic measurement of blood-to-brain and blood-to-tumour transport of (82)Rb. II: Clinical data and validation of technique
Abstract: Computer simulations and error analysis of a simple two-compartment, passive-diffusion exchange model for 82Rb across the blood-brain-barrier (BBB) have demonstrated the feasibility of obtaining useful estimates of unidirectional rate constant (K1) and tissue-blood water volume (Vb) in vivo using dynamic positron tomography (PET). The coefficients of variation (CV) in parameter estimates for 20 studies on ten patients are shown to have mean values of 10% for tumour K1 and Vb, 6% for normal brain Vb and 30% for normal brain K 1. Ten test-retest studies show a very high correlation (R 2>0.88) between the estimated parameter values. Apparent tissue blood volume (Vb) estimates obtained from 82Rb studies underestimate the blood volumes obtained by single-breath C15O studies by approximately 15%. The data from these clinical studies are in agreement with the predictions of the computer simulations and suggest the suitability of 82Rb/PET in the quantification of BBB functional changes.
Keywords: adolescent; adult; clinical article; middle aged; positron emission tomography; brain tumor; methodology; brain neoplasms; blood; blood brain barrier; blood-brain barrier; tomography, emission-computed; rubidium 82; humans; human; male; female; priority journal; article; rubidium radioisotopes
Journal Title: Physics in Medicine and Biology
Volume: 34
Issue: 12
ISSN: 0031-9155
Publisher: IOP Publishing Ltd  
Date Published: 1989-12-01
Start Page: 1785
End Page: 1794
Language: English
DOI: 10.1088/0031-9155/34/12/003
PUBMED: 2616638
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024388791&doi=10.1088%2f0031-9155%2f34%2f12%2f003&partnerID=40&md5=9c8cfd78e6cadc1a6b8bf9290b3409c2
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. David A. Rottenberg
    41 Rottenberg
  2. Stephen C. Strother
    24 Strother
  3. Vijay Dhawan
    22 Dhawan
  4. James Moeller
    17 Moeller
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