Effect of selecting a fixed dephosphorylation rate on the estimation of rate constants and rCMFGlu from dynamic [(18)F]fluorodeoxyglucose/PET data Journal Article


Authors: Dhawan, V.; Moeller, J. R.; Strother, S. C.; Evans, A. C.; Rottenberg, D. A.
Article Title: Effect of selecting a fixed dephosphorylation rate on the estimation of rate constants and rCMFGlu from dynamic [(18)F]fluorodeoxyglucose/PET data
Abstract: Several publications have discussed the estimation and physiologic significance of regional [18F]fluorodeoxyglucose (FDG) rate constants and metabolic rates. Most of these studies analyzed dynamic data collected over 45-60 min; three rate constants (k1-k3) and blood volume (V(b)) were estimated and the regional cerebral metabolic rate for glucose (rCmRGlu) was subsequently derived using the measured blood glucose value and a regionally invariant value of the lumped constant (LC). The dephosphorylation rate constant (k4) was either neglected, or a fixed value was used in the estimation procedure to obtain the remaining parameters. To compare the rate constants obtained by different authors using different values of k4 is impossible without knowledge of the effect of selecting different fixed values of k4 (including zero) on the estimated rate constants and rCMRGlu. Based on our analysis of FDG/PET data from nine normal volunteer subjects, we conclude that inclusion of a fixed value for k4, in spite of a scaling effect on the absolute values of model parameters, has no effect on the coefficient of variation (CV) of within- and between-subject parameter estimates and glucose metabolic rates.
Keywords: adult; positron emission tomography; phosphorylation; time factors; brain; glucose; radioisotope; fluorine 18; brain blood flow; intravenous drug administration; normal human; tomography, emission-computed; computer analysis; fluorine radioisotopes; dephosphorylation; brain metabolism; deoxyglucose; fludeoxyglucose f 18; human; priority journal; support, u.s. gov't, p.h.s.; deoxy sugars
Journal Title: Journal of Nuclear Medicine
Volume: 30
Issue: 9
ISSN: 0161-5505
Publisher: Society of Nuclear Medicine  
Date Published: 1989-09-01
Start Page: 1483
End Page: 1488
Language: English
PUBMED: 2788721
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Vijay Dhawan
    22 Dhawan
  2. James Moeller
    17 Moeller