The metabolic landscape of cortico-basal ganglionic degeneration: Regional asymmetries studied with positron emission tomography Journal Article
| Authors: | Eidelberg, D.; Dhawan, V.; Moeller, J. R.; Sidtis, J. J.; Ginos, J. Z.; Strother, S. C.; Cederbaum, J.; Greene, P.; Fahn, S.; Powers, J. M.; Rottenberg, D. A. |
| Article Title: | The metabolic landscape of cortico-basal ganglionic degeneration: Regional asymmetries studied with positron emission tomography |
| Abstract: | Regional metabolic rate for glucose (rCMRGlc) was estimated using [ 18F]fluorodeoxyglucose (FDG) and positron emission tomography (PET) in five patients (four men, one woman; mean age 68; mean disease duration 2-4 years) with clinical findings consistent with the syndrome of cortico-basal ganglionic degeneration (CBGD). Left-right rCMRGlc asymmetry, (L - R)/(L + R) × 100, was calculated for 13 grey matter regions and compared with regional metabolic data from 18 normal volunteers and nine patients with asymmetrical Parkinson's disease (PD). In the CBGD group mean metabolic asymmetry values in the thalamus, inferior parietal lobule and hippocampus were greater than those measured in normal control subjects and patients with asymmetrical PD (p < 0 02). Parietal lobe asymmetry of 5% or more was evident in all CBGD patients, whereas in PD patients and normal controls, all regional asymmetry measures were less than 5% in absolute value. Measures of frontal, parietal and hemispheric metabolic asymmetry were found to be positively correlated with asymmetries in thalamic rCMRGlc (p < 0 05). The presence of cortico-thalamic metabolic asymmetry is consistent with the focal neuropathological changes reported in CBGD brains. Our findings suggest that metabolic asymmetries detected with FDG/PET may support a diagnosis of CBGD in life. |
| Keywords: | adult; clinical article; controlled study; aged; case report; atrophy; syndrome; glucose; blood glucose; disease duration; cerebral cortex; nerve cell; tremor; energy metabolism; brain region; volunteer; neuropathology; neurology; nerve cell degeneration; rigidity; neurologic examination; leg; parietal lobe; tomography, emission-computed; nerve degeneration; hippocampus; glucose metabolism; gray matter; muscle rigidity; thalamus; arm; parkinsonism; emission tomography; dominance, cerebral; pyramidal tracts; deoxyglucose; basal ganglion; bradykinesia; degeneration; fludeoxyglucose f 18; human; male; female; priority journal; article; metabolic rate; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; basal ganglia diseases; parkinson disease, secondary; brain asymmetry; apraxias |
| Journal Title: | Journal of Neurology Neurosurgery and Psychiatry |
| Volume: | 54 |
| Issue: | 10 |
| ISSN: | 0022-3050 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 1991-10-01 |
| Start Page: | 856 |
| End Page: | 862 |
| Language: | English |
| DOI: | 10.1136/jnnp.54.10.856 |
| PUBMED: | 1744638 |
| PROVIDER: | scopus |
| PMCID: | PMC1014567 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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