Scaled subprofile model: A statistical approach to the analysis of functional patterns in positron emission tomographic data Journal Article
| Authors: | Moeller, J. R.; Strother, S. C.; Sidtis, J. J.; Rottenberg, D. A. |
| Article Title: | Scaled subprofile model: A statistical approach to the analysis of functional patterns in positron emission tomographic data |
| Abstract: | The data obtained from measurements of regional rCMRglu using [18F]fluorodeoxyglucose (FDG)/positron emission tomographic (PET) data contain more structure than can be identified with group mean rCMRglu profiles or regional correlation coefficients. This additional structure is revealed by a novel mathematical-statistical model of regional metabolic interactions that explicitly represents rCMRglu profiles as a combination of region-independent global effects, a group mean pattern and a mosaic of interacting networks. In its application to FDG/PET data, this model removes global subject effects [global scaling factors (GSFs)] and a group mean pattern (profile) so as to maximize statistical power for the detection and simultaneous discovery of all networks of two or more regions that form a significant and consistent linearly covarying pattern. The model approach presented here was applied to the combined rCMRglu data from 12 demented AIDS patients and 18 normal controls: Two significant metabolic covariance pattern descriptors that together accounted for 71 to 96% of the rCMRglu/GSF variation across subjects for 22/28 regions in the AIDS group were extracted. Each descriptor was found to be highly correlated with performance on several neuropsychological tests, providing independent validation of the analysis technique as a means of discovering and describing behaviorally related components of group rCMRglu profiles. |
| Keywords: | adult; metabolism; biological model; statistics; diagnostic agent; brain; fluorodeoxyglucose f 18; computer assisted emission tomography; fluorodeoxyglucose f18; drug derivative; glucose; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; tomography, emission-computed; models, neurological; deoxyglucose; humans; human; article |
| Journal Title: | Journal of Cerebral Blood Flow and Metabolism |
| Volume: | 7 |
| Issue: | 5 |
| ISSN: | 0271-678X |
| Publisher: | Sage Publications Ltd. |
| Date Published: | 1987-10-01 |
| Start Page: | 649 |
| End Page: | 658 |
| Language: | English |
| DOI: | 10.1038/jcbfm.1987.118 |
| PUBMED: | 3498733 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 5 February 2021 -- Source: Scopus |
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41Rottenberg -
24Strother -
18Sidtis -
17Moeller
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