Positron emission tomographic measurement of blood-to-brain and blood-to-tumour transport of (82)Rb. I: Error analysis and computer simulations Journal Article

  


Authors: Dhawan, V.; Poltorak, A.; Moeller, J. R.; Jarden, J. O.; Strother, S. C.; Thaler, H.; Rottenberg, D. A.
Article Title: Positron emission tomographic measurement of blood-to-brain and blood-to-tumour transport of (82)Rb. I: Error analysis and computer simulations
Abstract: Unidirectional blood-to-brain and blood-to-tumour transport rate constants (K1) for 82Rb (half-life 76 s) and plasma water volume per unit mass of brain/tumour tissue (Vp) can be estimated in vivo using dynamic positron emission tomography (PET). The accuracy of these estimates depends upon the accuracy of PET measurements of regional brain/tumour radioactivity and scintillation well detector measurements of whole-blood radioactivity, which, in turn, depend upon the time course of arterial blood radioactivity. A two-compartmental model has been employed to derive estimates for K1, k2 (efflux rate constant) and Vp from 82Rb/PET data. Errors in these parameter estimates have been studied (1) qualitatively using sensitivity function analysis and (2) quantitatively using computer simulations. The effect of adding a third irreversible compartment and its unidirectional rate constant, k3, has also been investigated. The advantages and disadvantages of bolus injection vs continuous infusion protocols are discussed.
Keywords: positron emission tomography; brain tumor; methodology; neoplasms; models, biological; blood; blood brain barrier; blood-brain barrier; computer simulation; theoretical study; tomography, emission-computed; computer analysis; rubidium 82; humans; priority journal; article; rubidium radioisotopes
Journal Title: Physics in Medicine and Biology
Volume: 34
Issue: 12
ISSN: 0031-9155
Publisher: IOP Publishing Ltd  
Date Published: 1989-12-01
Start Page: 1773
End Page: 1784
Language: English
DOI: 10.1088/0031-9155/34/12/002
PUBMED: 2616637
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024408687&doi=10.1088%2f0031-9155%2f34%2f12%2f002&partnerID=40&md5=933dd275635a80590055cecef804ffb9
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Howard T Thaler
    245 Thaler
  2. David A. Rottenberg
    41 Rottenberg
  3. Stephen C. Strother
    24 Strother
  4. Vijay Dhawan
    22 Dhawan
  5. James Moeller
    17 Moeller
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