Opening the blood-brain and blood-tumor barriers in experimental rat brain tumors: The effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow Journal Article

  

Authors:	Hiesiger, E. M.; Voorhies, R. M.; Basler, G. A.; Lipschutz, L. E.; Posner, J. B.; Shapiro, W. R.
Article Title:	Opening the blood-brain and blood-tumor barriers in experimental rat brain tumors: The effect of intracarotid hyperosmolar mannitol on capillary permeability and blood flow
Abstract:	Using quantitative autoradiography, we investigated the effect of intracarotid infusions of hyperosmolar mannitol solutions on capillary permeability and blood flow. Capillary permeability, expressed in terms of a blood‐to‐tissue transfer constant (K), was determined in two rat brain tumor models by measuring the entry of 14C‐alpha aminoisobutyric acid into brian tumor, into brain tissue adjacent to tumor, and into cortex. Cerebral blood flow was determined by measuring the uptake of 14C‐iodoantipyrine in one rat brain tumor model. Blood flow was examined in the same regions as K, as well as in the corpus callosum. Before mannitol administration, K values in both Walker 256 (W256) carcinosarcoma and C6 gliomas were much higher than those in cortex. C6 gliomas were about three times more permeable than were W256 tumors. There was a direct correlation between tumor size and increased capillary permeability. Mannitol at a concentration of 1.37 M did not increase the K values for either tumor or adjacent tissue. At 1.6 M, mannitol increased the K values for both tumors (1.7‐fold in C6 glioma and 13‐fold in W256) as well as for adjacent tissue. At both concentrations, mannitol markedly increased cortical K values in all groups: by 48‐to 72‐fold at 1.37 M and by 90‐ to 105‐fold at 1.6 M. The net effect of the mannitol was to reverse the tumor‐to‐cortex permeability relationship. Cortical blood flow increased modestly after intracarotid mannitol administration on both sides of the brain. These data provide little justification for using intracarotid mannitol during chemotherapy of human brain tumors. Copyright © 1986 American Neurological Association
Keywords:	unclassified drug; drug efficacy; nonhuman; chemotherapy; brain tumor; glioma; brain neoplasms; animals; animal model; central nervous system; rat; blood brain barrier; blood-brain barrier; intraarterial drug administration; rats; radioisotope; cerebral cortex; mannitol; brain blood flow; cerebrovascular circulation; autoradiography; nervous system; carcinosarcoma; regional blood flow; tumor blood flow; capillary permeability; injections, intra-arterial; carotid arteries; rats, inbred strains; osmolar concentration; male; priority journal; article; blood and hemopoietic system; peripheral vascular system; 2 amino 2 methylpropionic acid c 14; iodophenazone c 14
Journal Title:	Annals of Neurology
Volume:	19
Issue:	1
ISSN:	0364-5134
Publisher:	Wiley Blackwell
Date Published:	1986-01-01
Start Page:	50
End Page:	59
Language:	English
DOI:	10.1002/ana.410190110
PUBMED:	3080944
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022624007&doi=10.1002%2fana.410190110&partnerID=40&md5=a4f4ce0343d5161cecaa29b6519411e8
Notes:	Article -- Export Date: 18 August 2021 -- Source: Scopus

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