Acute effects of low-dose cranial irradiation on regional capillary permeability in experimental brain tumors Journal Article
| Authors: | Delattre, J. Y.; Shapiro, W. R.; Posner, J. B. |
| Article Title: | Acute effects of low-dose cranial irradiation on regional capillary permeability in experimental brain tumors |
| Abstract: | To determine the acute effects of low-dose cranial irradiation (CRT) on regional capillary permeability (RCP) of normal brain, brain tumor and damaged brain surrounding the tumor, we used quantitative autoradiography (QAR) to measure regional blood-to-tissue transport (K) of [14C]aminoisobutyric acid (AIB) in experimental C6 brain tumors 3-4 h after a single dose of 3 Gy CRT. K increased 63% in cortex, 30% in basal ganglia and 31% in brain surrounding the tumor (BST) vs. controls (P < 0.005). K did not change in the tumor or in the brain adjacent to the tumor (BAT), suggesting that capillaries of normal parenchyma are more sensitive to the acute effects of CRT than capillaries of damaged parenchyma or tumor. © 1989. |
| Keywords: | nonhuman; brain tumor; glioma; brain neoplasms; animal cell; animal; animal experiment; animal model; cranial irradiation; rat; blood brain barrier; blood-brain barrier; irradiation; neoplasms, experimental; rats; radioisotope; image processing, computer-assisted; cerebrovascular circulation; autoradiography; capillary permeability; rats, inbred strains; aminoisobutyric acids; male; priority journal; experimental brain tumor |
| Journal Title: | Journal of the Neurological Sciences |
| Volume: | 90 |
| Issue: | 2 |
| ISSN: | 0022-510X |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1989-04-01 |
| Start Page: | 147 |
| End Page: | 153 |
| Language: | English |
| DOI: | 10.1016/0022-510x(89)90097-x |
| PUBMED: | 2723679 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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