Carboplatin‐associated thrombotic microangiopathic hemolytic anemia Journal Article
| Authors: | Walker, R. W.; Rosenblum, M. K.; Kempin, S. J.; Christian, M. C. |
| Article Title: | Carboplatin‐associated thrombotic microangiopathic hemolytic anemia |
| Abstract: | Thrombotic microangiopathic hemolytic anemia has been associated with several chemotherapeutic agents. The authors describe a patient who developed this syndrome while receiving carboplatin, an analog of cisplatin. The clinical course was marked by encephalopathy and multifocal neurologic deficits. Progressive brainstem dysfunction culminated in coma and respiratory arrest. Pathologic examination revealed widespread microvascular thrombosis, particularly severe in the heart, kidney, and brain. Although the pathogenesis of chemotherapy‐related thrombotic microangiopathy remains unclear, an elevated von Willebrand factor antigen and pathologic evidence of endothelial hyperplasia in this patient suggest that an abnormality of the endothelium is related to the development of the clinical syndrome. Copyright © 1989 American Cancer Society |
| Keywords: | cancer chemotherapy; case report; antineoplastic agents; carboplatin; histology; age; kidney; brain; thrombosis; medulloblastoma; hemolytic anemia; organoplatinum compounds; cerebellar neoplasms; coronary vessels; thrombotic thrombocytopenic purpura; myocardium; fatality; middle age; arteries; capillaries; human; female; priority journal; anemia, hemolytic; arterioles |
| Journal Title: | Cancer |
| Volume: | 64 |
| Issue: | 5 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1989-09-01 |
| Start Page: | 1017 |
| End Page: | 1020 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19890901)64:5<1017::Aid-cncr2820640508>3.0.Co;2-n |
| PUBMED: | 2667747 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work