Thrombotic microangiopathy as a complication of long-term therapy with gemcitabine Journal Article
| Authors: | Flombaum, C. D.; Mouradian, J. A.; Casper, E. S.; Erlandson, R. A.; Benedetti, F. |
| Article Title: | Thrombotic microangiopathy as a complication of long-term therapy with gemcitabine |
| Abstract: | Three patients with pancreatic carcinoma treated with gemcitabine for 1 year developed clinical and laboratory findings compatible with an indolent form of the hemolytic-uremic syndrome. Renal biopsy specimens in two of these patients showed the characteristic features of thrombotic microangiopathy, and a skin biopsy specimen from the third patient, who presented with livedo reticularis, showed intravascular fibrin deposition. Thrombotic microangiopathy may represent a toxic effect of long-term gemcitabine therapy. |
| Keywords: | adult; aged; clinical feature; case report; drug safety; gemcitabine; pancreatic neoplasms; antimetabolites, antineoplastic; skin biopsy; creatinine; pancreas carcinoma; kidney; thrombosis; long term care; microcirculation; deoxycytidine; hemolytic uremic syndrome; thrombotic thrombocytopenic purpura; hemolytic-uremic syndrome; hemoglobins; haptoglobins; thrombotic microangiopathy; humans; human; male; female; article |
| Journal Title: | American Journal of Kidney Diseases |
| Volume: | 33 |
| Issue: | 3 |
| ISSN: | 0272-6386 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 1999-03-01 |
| Start Page: | 555 |
| End Page: | 562 |
| Language: | English |
| PUBMED: | 10070921 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0272-6386(99)70194-0 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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