Cerebral infarction from non-bacterial thrombotic endocarditis: Clinical and pathological study including the effects of anticoagulation Journal Article

  

Authors:	Rogers, L. R.; Cho, E. S.; Kempin, S.; Posner, J. B.
Article Title:	Cerebral infarction from non-bacterial thrombotic endocarditis: Clinical and pathological study including the effects of anticoagulation
Abstract:	The clinical and pathologic findings in 42 autopsy proved cases of cerebral infarction from cancer-associated non-bacterial thrombotic endocarditis were reviewed. Carcinoma of the lung was the most common malignancy. Most patients had disseminated cancer, but in six patients, the condition was stable or in remission, and six patients had localized cancer; two patients were not known to have cancer until neurologic symptoms developed. Neurologic symptoms were focal, suggesting stroke in 18; diffuse, suggesting metabolic encephalopathy in nine; and mixed in five. Neurologic signs were often the only evidence of thromboembolism. The definitive diagnostic test was cerebral angiography showing multiple arterial occlusions. Anticoagulation with heparin appeared to help some patients and did not promote brain hemorrhage. Early diagnosis and vigorous treatment of non-bacterial endocarditis may prevent severe neurologic disability. © 1997.
Keywords:	adult; aged; review; case report; adenocarcinoma; lung neoplasms; lung cancer; gastrointestinal neoplasms; brain; thromboembolism; thrombosis; heparin; anticoagulation; autopsy; cerebral infarction; brain infarction; middle age; disseminated intravascular coagulation; endocarditis; human; male; female; thrombotic endocarditis
Journal Title:	The American Journal of Medicine
Volume:	83
Issue:	4
ISSN:	0002-9343
Publisher:	Elsevier Inc.
Date Published:	1987-10-01
Start Page:	746
End Page:	756
Language:	English
DOI:	10.1016/0002-9343(87)90908-9
PUBMED:	3674060
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0023625678&doi=10.1016%2f0002-9343%2887%2990908-9&partnerID=40&md5=354657e6fa364625d6da219ed65e9175
Notes:	Article -- Export Date: 5 February 2021 -- Source: Scopus

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