Leukemic differentiation of a mediastinal germ cell tumor Journal Article
| Authors: | Chaganti, R. S. K.; Ladanyi, M.; Samaniego, F.; Offit, K.; Reuter, V. E.; Jhanwar, S. C.; Bosl, G. J. |
| Article Title: | Leukemic differentiation of a mediastinal germ cell tumor |
| Abstract: | The biological basis for acute leukemia associated with mediastinal germ cell tumors has remained unexplained due to lack of critical data that would illuminate the genetic relationship between the two tumors in a given patient. Here we present results of serial cytogenetic investigations on the pretreatment and posttreatment mediastinal yolk sac tumor and immature teratoma biopsies and two separate leukemic bone marrow aspirates from a patient who developed acute nonlymphocytic leukemia 11 months after the initial diagnosis of the germ cell tumor. Presence of an i(12p) in all tumor clones and trisomy 21 in one clone in the posttreatment mediastinal tumor and all leukemic clones establishes the common origin of all tumor clones and shows that in this case the leukemia was derived from the malignant germ cell clone. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | adult; human cell; case report; cytology; heredity; bone marrow; cell differentiation; teratoma; neoplasms, germ cell and embryonal; germ cell tumor; mediastinal neoplasms; karyotyping; neoplasms, multiple primary; chromosome 12p; acute nonlymphocytic leukemia; mesonephroma; leukemia, nonlymphocytic, acute; isochromosome; human; male; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Genes Chromosomes and Cancer |
| Volume: | 1 |
| Issue: | 1 |
| ISSN: | 1045-2257 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 1989-09-01 |
| Start Page: | 83 |
| End Page: | 87 |
| Language: | English |
| DOI: | 10.1002/gcc.2870010113 |
| PUBMED: | 2562115 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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