Abnormalities of 2q: A common genetic link between rhabdomyosarcoma and hepatoblastoma? Journal Article
| Authors: | Rodriguez, E.; Reuter, V. E.; Mies, C.; Bosl, G. J.; Chaganti, R. S. K. |
| Article Title: | Abnormalities of 2q: A common genetic link between rhabdomyosarcoma and hepatoblastoma? |
| Abstract: | Cytogenetic and restriction fragment length polymorphism (RFLP) analyses were performed on a mediastinal germ cell tumor comprising distinct teratoma and embryonal rhabdomyosarcoma components in a 31‐year‐old male and a hepatoblastoma in a 2 month‐old male child. Clonal relationship between the teratoma and rhabdomyosarcoma of the germ cell tumor was established by the presence in both of i(12p), the characteristic marker of germ cell tumors. Both the rhabdomyosarcoma component of the mediastinal germ cell tumor and the hepatoblastoma exhibited rearrangements of 2q. These data suggest that malignant differentiation of a teratoma is accompanied by the development of chromosome abnormalities specific for the transformed histology and further suggest that 2q abnormalities may be the common genetic link in the development of the two histologically unrelated tumor types, embryonal rhabdomyosarcoma and hepatoblastoma. Copyright © 1991 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | adult; child; human cell; case report; carcinoma, hepatocellular; liver neoplasms; tumor markers, biological; cell differentiation; chromosomes, human, pair 2; chromosome aberration; infant; cell transformation; teratoma; chromosome aberrations; rhabdomyosarcoma; mediastinal neoplasms; neoplasms, multiple primary; genetic markers; chromosome 2q; polymorphism, restriction fragment length; hepatoblastoma; human; male; article; support, u.s. gov't, p.h.s. |
| Journal Title: | Genes Chromosomes and Cancer |
| Volume: | 3 |
| Issue: | 2 |
| ISSN: | 1045-2257 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 1991-03-01 |
| Start Page: | 122 |
| End Page: | 127 |
| Language: | English |
| DOI: | 10.1002/gcc.2870030207 |
| PUBMED: | 1676906 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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