Origin of adult male mediastinal germ-cell tumours Journal Article
| Authors: | Chaganti, R. S. K.; Rodriguez, E.; Mathew, S. |
| Article Title: | Origin of adult male mediastinal germ-cell tumours |
| Abstract: | The origin of primary extragonadal germ-cell tumours, especially mediastinal and pineal germ-cell tumours in adult males remains uncertain, although the predominant view is that they originate in misplaced primordial germ cells retained in extra-gonadal sites, in contrast to gonadal germ-cell tumours which are considered to arise in premeiotic spermatocytes. We hypothesised that if mediastinal germ-cell tumours and gonadal germ-cell tumours were derived from precursor cells in different developmental states and in different cellular environments, non-random genetic changes in the two groups would be significantly different. To test this hypothesis, we compared non-random chromosomal abnormalities in mediastinal germ-cell tumours with those in gonadal germ-cell tumours. Our results show that although the two groups differed in the composition of histological subsets, their non-random chromosomal changes were essentially the same. These data suggest gonadal origin of all germ-cell tumours with occasional migration of precursors early in development to extragonadal sites to become established as primary extragonadal germ-cell tumours. Based on a review of cytogenetic data on carcinoma in situ, primary mediastinal and gonodal germ-cell tumours, embryonal migration of primordial germ-cells, and meiotic behaviour of spermatocytes, a model of origin of all germ-cell tumours in males is suggested. © 1994. |
| Keywords: | adult; controlled study; human tissue; comparative study; neoplasm staging; meiosis; spermatocytes; incidence; cytogenetics; biopsy; models, genetic; chromosome aberrations; mediastinum; germ cell tumor; mediastinal neoplasms; karyotyping; germinoma; chromosome disorders; human; male; priority journal; article; support, u.s. gov't, p.h.s.; neoplasms, gonadal tissue |
| Journal Title: | Lancet |
| Volume: | 343 |
| Issue: | 8906 |
| ISSN: | 0140-6736 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1994-05-07 |
| Start Page: | 1130 |
| End Page: | 1132 |
| Language: | English |
| DOI: | 10.1016/s0140-6736(94)90235-6 |
| PROVIDER: | scopus |
| PUBMED: | 7910232 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: LANCA C2 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work