Metabolism and the leukemic stem cell Journal Article

   


Authors: Abdel-Wahab, O.; Levine, R. L.
Article Title: Metabolism and the leukemic stem cell
Abstract: Acute leukemias are clonal disorders of hematopoiesis wherein a leukemic stem cell (LSC) acquires mutations that confer the capacity for unlimited self-renewal, impaired hematopoietic differentiation, and enhanced proliferation to the leukemic clone. Many recent advances in understanding the biology of leukemia have come from studies defining specific genetic and epigenetic abnormalities in leukemic cells. Three recent articles, however, further our understanding of leukemia biology by elucidating specific abnormalities in metabolic pathways in leukemic hematopoiesis. These studies potentially converge on the concept that modulation of reactive oxygen species (ROS) abundance may influence the pathogenesis and treatment of acute myeloid leukemia (AML). © 2010 Abdel-Wahab and Levine.
Keywords: leukemia; acute granulocytic leukemia; gene mutation; leukemia, myeloid, acute; mutation, missense; note; cell proliferation; animals; models, biological; cell renewal; cell differentiation; stem cell; acute leukemia; neoplastic stem cells; epigenetics; leukemia cell; hematopoietic stem cells; reactive oxygen species; reactive oxygen metabolite; hematopoiesis; hematopoietic stem cell; hypoxia inducible factor 1alpha; hypoxia-inducible factor 1, alpha subunit; isocitrate dehydrogenase; iron chelation; cholecalciferol; glutarates; iron chelating agents; jnk mitogen-activated protein kinases; nadp
Journal Title: Journal of Experimental Medicine
Volume: 207
Issue: 4
ISSN: 0022-1007
Publisher: Rockefeller University Press  
Date Published: 2010-04-12
Start Page: 677
End Page: 680
Language: English
DOI: 10.1084/jem.20100523
PUBMED: 20368582
PROVIDER: scopus
PMCID: PMC2856035
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77951040369&partnerID=40&md5=dcbf9e289da18173e0342069d5030052
Notes: --- - "Cited By (since 1996): 6" - "Export Date: 20 April 2011" - "CODEN: JEMEA" - "Source: Scopus"
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MSK Authors
  1. Ross Levine
    775 Levine
  2. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
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