Lymphoblastic lymphoma in adults Journal Article

  


Authors: Slater, D. E.; Mertelsmann, R.; Koziner, B.; Higgins, C.; McKenzie, S.; Schauer, P.; Gee, T.; Straus, D.; Kempin, S.; Arlin, Z.; Clarkson, B. D.
Article Title: Lymphoblastic lymphoma in adults
Abstract: Fifty-one patients with lymphoblastic lymphoma (LBL) treated with one of five successive intensive chemotherapy protocols for acute lymphoblastic leukemia (ALL) since 1971 were reviewed. The patients were divided into leukemic and nonleukemic groups, and their clinical and laboratory parameters compared. The projected 5-year survival rate for all patients treated with the L10/17 protocols was 45% for both leukemic and nonleukemic LBL. The response to treatment was compared with that of 111 patients with ALL and was nearly identical. Poor prognostic factors were age beyond 30, WBC > 50,000/μL, failure to achieve a complete response (CR), and a late CR during induction. Leukemia at presentation, T cell surface markers, and the presence of a mediastinal mass did not adversely affect survival. The use of intensive chemotherapy protocols has proven to be a significant advance in the treatment of LBL.
Keywords: survival; leukemia; major clinical study; prednisone; cancer combination chemotherapy; drug efficacy; chemotherapy; cytarabine; methotrexate; cyclophosphamide; vincristine; carmustine; age; lymphatic system; lymphoma; daunorubicin; dactinomycin; asparaginase; acute lymphocytic leukemia; drug therapy; therapy; tioguanine; intravenous drug administration; mercaptopurine; lymphoblastoma; prognosis; human; priority journal; blood and hemopoietic system
Journal Title: Journal of Clinical Oncology
Volume: 4
Issue: 1
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 1986-01-01
Start Page: 57
End Page: 67
Language: English
DOI: 10.1200/jco.1986.4.1.57
PROVIDER: scopus
PUBMED: 3510283
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022622602&doi=10.1200%2fJCO.1986.4.1.57&partnerID=40&md5=aaff1d579d0209f654ccb0d5672a6c20
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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MSK Authors
  1. David J Straus
    356 Straus
  2. Bayard Clarkson
    220 Clarkson
  3. Susan Mckenzie
    16 Mckenzie
  4. Timothy Gee
    46 Gee
  5. Sanford Kempin
    35 Kempin
  6. Benjamin Koziner
    52 Koziner
  7. Roland Mertelsmann
    32 Mertelsmann
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