Combined segregation and linkage analysis for IDDM and HLA‐DR under several ascertainment assumptions Journal Article
| Authors: | Pascoe, L.; Sherman, S.; Wu, D.; Becker, M.; Falk, C. |
| Article Title: | Combined segregation and linkage analysis for IDDM and HLA‐DR under several ascertainment assumptions |
| Abstract: | Combined segregation and linkage analysis of the Genetic Analysis Workshop 5 (GAW5) data suggests a complex basis for susceptibility to insulin‐dependent diabetes mellitus (IDDM). One susceptibility gene, linked to the HLA‐DR region, is additive on the liability scale (d = .49 ± .15,t = 2.9 ± .6) with a gene frequency q = .30 ± .03. A second locus, with a gene frequency of q = .07 ± .02, which is recessive and unlinked to HLA, is also suggested by the analysis. The ascertainment correction used has little effect on the results, presumably because most of the information comes from the cosegregation of HLA alleles and disease status. The results are consistent with a direct involvement of the HLA‐DR region in susceptibility, but are not a proof of it. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | heredity; hla dr antigen; hla-dr antigens; models, genetic; computer simulation; insulin dependent diabetes mellitus; genes, mhc class ii; genetic model; linkage (genetics); genetic linkage; segregation analysis; linkage analysis; human; diabetes mellitus, insulin-dependent; ascertainment; genetic models; iddm susceptibility |
| Journal Title: | Genetic Epidemiology |
| Volume: | 6 |
| Issue: | 1 |
| ISSN: | 0741-0395 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 1989-01-01 |
| Start Page: | 131 |
| End Page: | 136 |
| Language: | English |
| DOI: | 10.1002/gepi.1370060125 |
| PUBMED: | 2499499 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work