Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2 Journal Article
| Authors: | Ayyoub, M.; Merlo, A.; Hesdorffer, C. S.; Speiser, D.; Rimoldi, D.; Cerottini, J. C.; Ritter, G.; Chen, Y. T.; Old, L. J.; Stevanovic, S.; Valmori, D. |
| Article Title: | Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2 |
| Abstract: | Because of their specific expression in tumors of different histological types, the products of the SSX genes are important candidate targets for development of cancer vaccines. We have previously identified two immunodominant SSX-2-derived T cell epitopes recognized by HLA-A2-restricted CD8 + T cells (SSX-2 41-49) and HLA-DR11-restricted CD4 + T cells (SSX-2 45-59), respectively. In this study, we report the identification of an HLA-DR3-restricted epitope mapping to the 37-51 region of SSX-2, overlapping both previously identified epitopes. As about one fifth of individuals from several major ethnic groups express HLA-DR3, the identification of this epitope significantly increases the percent of patients that are expected to mount specific CD4 + T cell responses following vaccination with peptides in this region of SSX-2. Retrieval of multiple overlapping epitopes in a defined region of SSX-2 protein suggests the presence of a "hot spot" for T cell recognition that may prove sufficient for the induction of immune responses. © 2004 Elsevier Inc. All rights reserved. |
| Keywords: | controlled study; unclassified drug; human cell; promoter region; cd8 antigen; gene; cells, cultured; melanoma; gene expression; neoplasm proteins; alleles; tumor antigen; gene mapping; statistical significance; immune response; amino acid sequence; molecular sequence data; immunotherapy; antigen specificity; gene identification; hla dr antigen; cd4-positive t-lymphocytes; epitope mapping; hla-dr antigens; peptide fragments; vaccination; epitope; recombinant protein; t-lymphocytes, helper-inducer; cd4 antigen; epitopes, t-lymphocyte; repressor proteins; t lymphocyte activation; helper cell; hla system; hla a2 antigen; ethnology; ear reconstruction; peptide derivative; restriction mapping; cd4; + t cells; ssx-2; hla dr3 antigen; ssx 2 protein; ssx 2 gene; hla-dr3 antigen |
| Journal Title: | Clinical Immunology |
| Volume: | 114 |
| Issue: | 1 |
| ISSN: | 1521-6616 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-01-01 |
| Start Page: | 70 |
| End Page: | 78 |
| Language: | English |
| DOI: | 10.1016/j.clim.2004.08.014 |
| PUBMED: | 15596411 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 14" - "Export Date: 24 October 2012" - "CODEN: CLIIF" - "Source: Scopus" |
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