Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region Journal Article


Authors: Skibola, C. F.; Berndt, S. I.; Vijai, J.; Conde, L.; Wang, Z.; Yeager, M.; de Bakker, P. I. W.; Birmann, B. M.; Vajdic, C. M.; Foo, J. N.; Bracci, P. M.; Vermeulen, R. C. H.; Slager, S. L.; de Sanjose, S.; Wang, S. S.; Linet, M. S.; Salles, G.; Lan, Q.; Severi, G.; Hjalgrim, H.; Lightfoot, T.; Melbye, M.; Gu, J.; Ghesquieres, H.; Link. B. K.; Morton, L. M.; Holly, E. A.; Smith, A.; Tinker, L. F.; Tera, L. R.; Kricker, A.; Becker, N.; Purdue, M. P.; Spinelli, J. J.; Zhang, Y.; Giles, G. G.; Vineis, P.; Monnereau, A.; Bertrand, K. A.; Albanes, D.; Zeleniuch-Jacquotte, A.; Gabbas, A.; Chung, C. C.; Burdett, L.; Hutchinson, A.; Lawrence, C.; Montalvan, R.; Liang, L.; Huang, J.; Ma, B.; Liu, J.; Adami, H. O.; Glimelius, B.; Ye, Y.; Nowakowski, G. S.; Dogan, A.; Thompson, C. A.; Habermann, T. M.; Novak, A. J.; Liebow, M.; Witzig, T. E.; Weiner, G. J.; Schenk, M.; Hartge, P.; De Roos, A. J.; Cozen, W.; Zhi, D.; Aker, N. K.; Riby, J.; Smith, M. T.; Lacher, M.; Villano, D. J.; Maria, A.; Roman, E.; Kane, E.; Jackson, R. D.; North, K. E.; Diver, W. R.; Turner, J.; Armstrong, B. K.; Benavente, Y.; Boffetta, P.; Brennan, P.; Foretova, L.; Maynadie, M.; Staines, A.; McKay, J.; Brooks-Wilson, A. R.; Zheng, T.; Holford, T. R.; Chamosa, S.; Kaaks, R.; Kelly, R. S.; Ohlsson, B.; Travis, R. C.; Weiderpass, E.; Clavel, J.; Giovannucci, E.; Kraft, P.; Virtamo, J.; Mazza, P.; Cocco, P.; Grazia Ennas, M.; Chiu, B. C. H.; Fraumeni, J. F. Jr; Nieters, A.; Offit, K.; Wu, X.; Cerhan, J. R.; Smedby, K. E.; Chanock, S. J.; Rothman, N.
Article Title: Genome-wide association study identifies five susceptibility loci for follicular lymphoma outside the HLA region
Abstract: Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 x 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 x 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 x 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 x 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 x 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DR beta 1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (P-omnibus = 4.20 x 10(-67) to 2.67 x 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 x 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 x 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
Keywords: peptide; risk; university; expression; class-i; variants; resource; tool; set; snps
Journal Title: American Journal of Human Genetics
Volume: 95
Issue: 4
ISSN: 0002-9297
Publisher: Cell Press  
Date Published: 2014-10-01
Start Page: 462
End Page: 471
Language: English
ACCESSION: WOS:000342654300011
DOI: 10.1016/j.ajhg.2014.09.004
PROVIDER: wos
PMCID: PMC4185120
PUBMED: 25279986
Notes: Article -- Source: Wos
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MSK Authors
  1. Kenneth Offit
    494 Offit
  2. Vijai Joseph
    113 Joseph
  3. Mortimer J Lacher
    3 Lacher
  4. Ahmet Dogan
    162 Dogan
  5. Danylo Julian Villano
    13 Villano
  6. Ann   Maria
    7 Maria