Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer Journal Article
| Authors: | Wolpin, B. M.; Rizzato, C.; Kraft, P.; Kooperberg, C.; Petersen, G. M.; Wang, Z.; Arslan, A. A.; Beane-Freeman, L.; Bracci, P. M.; Buring, J.; Canzian, F.; Duell, E. J.; Gallinger, S.; Giles, G. G.; Goodman, G. E.; Goodman, P. J.; Jacobs, E. J.; Kamineni, A.; Klein, A. P.; Kolonel, L. N.; Kulke, M. H.; Li, D.; Malats, N.; Olson, S. H.; Risch, H. A.; Sesso, H. D.; Visvanathan, K.; White, E.; Zheng, W.; Abnet, C. C.; Albanes, D.; Andreotti, G.; Austin, M. A.; Barfield, R.; Basso, D.; Berndt, S. I.; Boutron-Ruault, M. C.; Brotzman, M.; Büchler, M. W.; Bueno-de-Mesquita, H. B.; Bugert, P.; Burdette, L.; Campa, D.; Caporaso, N. E.; Capurso, G.; Chung, C.; Cotterchio, M.; Costello, E.; Elena, J.; Funel, N.; Gaziano, J. M.; Giese, N. A.; Giovannucci, E. L.; Goggins, M.; Gorman, M. J.; Gross, M.; Haiman, C. A.; Hassan, M.; Helzlsouer, K. J.; Henderson, B. E.; Holly, E. A.; Hu, N.; Hunter, D. J.; Innocenti, F.; Jenab, M.; Kaaks, R.; Key, T. J.; Khaw, K. T.; Klein, E. A.; Kogevinas, M.; Krogh, V.; Kupcinskas, J.; Kurtz, R. C.; LaCroix, A.; Landi, M. T.; Landi, S.; Le Marchand, L.; Mambrini, A.; Mannisto, S.; Milne, R. L.; Nakamura, Y.; Oberg, A. L.; Owzar, K.; Patel, A. V.; Peeters, P. H. M.; Peters, U.; Pezzilli, R.; Piepoli, A.; Porta, M.; Real, F. X.; Riboli, E.; Rothman, N.; Scarpa, A.; Shu, X. O.; Silverman, D. T.; Soucek, P.; Sund, M.; Talar-Wojnarowska, R.; Taylor, P. R.; Theodoropoulos, G. E.; Thornquist, M.; Tjønneland, A.; Tobias, G. S.; Trichopoulos, D.; Vodicka, P.; Wactawski-Wende, J.; Wentzensen, N.; Wu, C.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Hoover, R.; Hartge, P.; Fuchs, C.; Chanock, S. J.; Stolzenberg-Solomon, R. S.; Amundadottir, L. T. |
| Article Title: | Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer |
| Abstract: | We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10-12), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10-10), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10-9) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10-8). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10-14). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10-7) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies. © 2014 Nature America, Inc. All rights reserved. |
| Keywords: | adult; controlled study; aged; unclassified drug; major clinical study; promoter region; single nucleotide polymorphism; case control study; exon; cancer risk; pancreas cancer; follow up; phenotype; gene locus; genetic association; genotype; gene frequency; genetic transcription; protein p53; extracellular matrix; gene mapping; genetic susceptibility; telomerase reverse transcriptase; cell migration; atm protein; ubiquitin protein ligase e3; cell cycle regulation; transcription factor pdx 1; genetic predisposition; cell adhesion; cytoskeleton; meta analysis; quantitative trait locus; enzyme active site; crk associated substrate protein; chromosome 13q; gene linkage disequilibrium; peptides and proteins; wnt signaling pathway; pvt1 protein; human; male; female; priority journal; article; chymotrypsinogen; clptm1l protein; ctrb1 protein; ctrb2 protein; linc pint protein; von willebrand factor cleaving proteinase; znrf3 protein |
| Journal Title: | Nature Genetics |
| Volume: | 46 |
| Issue: | 9 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2014-09-01 |
| Start Page: | 994 |
| End Page: | 1000 |
| Language: | English |
| DOI: | 10.1038/ng.3052 |
| PROVIDER: | scopus |
| PMCID: | PMC4191666 |
| PUBMED: | 25086665 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work