A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 Journal Article
| Authors: | Petersen, G. M.; Amundadottir, L.; Fuchs, C. S.; Kraft, P.; Stolzenberg-Solomon, R. Z.; Jacobs, K. B.; Arslan, A. A.; Bueno-de-Mesquita, H. B.; Gallinger, S.; Gross, M.; Helzlsouer, K.; Holly, E. A.; Jacobs, E. J.; Klein, A. P.; LaCroix, A.; Li, D.; Mandelson, M. T.; Olson, S. H.; Risch, H. A.; Zheng, W.; Albanes, D.; Bamlet, W. R.; Berg, C. D.; Boutron-Ruault, M. C.; Buring, J. E.; Bracci, P. M.; Canzian, F.; Clipp, S.; Cotterchio, M.; De Andrade, M.; Duell, E. J.; Gaziano, J. M.; Giovannucci, E. L.; Goggins, M.; Hallmans, G.; Hankinson, S. E.; Hassan, M.; Howard, B.; Hunter, D. J.; Hutchinson, A.; Jenab, M.; Kaaks, R.; Kooperberg, C.; Krogh, V.; Kurtz, R. C.; Lynch, S. M.; McWilliams, R. R.; Mendelsohn, J. B.; Michaud, D. S.; Parikh, H.; Patel, A. V.; Peeters, P. H. M.; Rajkovic, A.; Riboli, E.; Rodriguez, L.; Seminara, D.; Shu, X. O.; Thomas, G.; Tjønneland, A.; Tobias, G. S.; Trichopoulos, D.; Van Den Eeden, S. K.; Virtamo, J.; Wactawski-Wende, J.; Wang, Z.; Wolpin, B. M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Fraumeni, J. F.; Hoover, R. N.; Hartge, P.; Chanock, S. J. |
| Article Title: | A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 |
| Abstract: | We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 × 10 11, per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 × 10 8, per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 × 10 10, per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 × 10 7, per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies. © 2010 Nature America, Inc. All rights reserved. |
| Keywords: | signal transduction; gene mutation; single nucleotide polymorphism; case-control studies; polymorphism, single nucleotide; nonhuman; pancreas cancer; pancreatic neoplasms; follow up; cell cycle; cancer susceptibility; genetic predisposition to disease; cohort studies; gene expression; genotype; genome-wide association study; linkage disequilibrium; brca1 protein; brca2 protein; haplotype; carcinoma; chromosomes, human, pair 1; chromosome 1q; knockout mouse; genetic linkage; chromosome 13q; chromosome 5q; chromosomes, human, pair 5; chromosomes, human, pair 13; genetic loci |
| Journal Title: | Nature Genetics |
| Volume: | 42 |
| Issue: | 3 |
| ISSN: | 1061-4036 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-03-01 |
| Start Page: | 224 |
| End Page: | 228 |
| Language: | English |
| DOI: | 10.1038/ng.522 |
| PUBMED: | 20101243 |
| PROVIDER: | scopus |
| PMCID: | PMC2853179 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 28" - "Export Date: 20 April 2011" - "CODEN: NGENE" - "Source: Scopus" |
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