Definition of subchromosomal intervals around the myotonic dystrophy gene region at 19q Journal Article
| Authors: | Schonk, D.; Coerwinkel-Driessen, M.; van Dalen, I.; Oerlemans, F.; Smeets, B.; Schepens, J.; Hulsebos, T.; Cockburn, D.; Boyd, Y.; Davis, M.; Rettig, W.; Shaw, D.; Roses, A.; Ropers, H.; Wieringa, B. |
| Article Title: | Definition of subchromosomal intervals around the myotonic dystrophy gene region at 19q |
| Abstract: | The localization to 19q of the gene causing myotonic dystrophy (DM) has been defined more precisely by refinement of the physical location of several linked markers. A somatic cell hybrid mapping panel from cells with t(1;19), t(12;19), and t(X;19) translocation products was constructed to define five different intervals across 19q. In addition, we have derived a series of cell hybrids by irradiation of a der(19)-only hybrid to further subdivide the cen-q13.1 region. Using an array of 36 cloned genes, anonymous DNAs, and enzyme markers, we have tested the location of the panel breakpoints and refined the regional assignment of several of these markers. All markers tightly linked to DM are localized mainly within 19q13.2, thus suggesting that the DM gene is also close to this region. © 1989. |
| Keywords: | genetics; chromosome 19; mouse; animal; mice; species specificity; species difference; chromosomes, human, pair 19; nucleic acid hybridization; sequence homology; sequence homology, nucleic acid; ultrastructure; genetic marker; genetic markers; chromosome map; chromosome mapping; myotonic dystrophy; hybrid cell; hybrid cells; hamster; dna probes; human; article; support, non-u.s. gov't; dna probe; hamsters |
| Journal Title: | Genomics |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 0888-7543 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1989-04-01 |
| Start Page: | 384 |
| End Page: | 396 |
| Language: | English |
| DOI: | 10.1016/0888-7543(89)90346-7 |
| PUBMED: | 2714797 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
