| Abstract: |
The gene for myotonic dystrophy (DM) is located on the proximal long arm of chromosome 19 along with at least 10 cloned genes and anonymous DNA segments. In order to refine the map of this region of the chromosome, we have constructed somatic cell hybrid lines from fibroblasts carrying a balanced translocation t(1, 19) with a breakpoint at 19q12. We have established that D19S7 is the most proximal of the available long-arm markers and confirmed that PEDD localizes to 19q, along with PVS, MSK19, and MSK37. We have also examined the segregation of markers from the proximal long-arm region of chromosome 19 in hybrids containing fragments of this chromosome. © 1987. |
| Keywords: |
genetics; chromosome 1; chromosome 19; mouse; animal; mice; cell line; monoclonal antibody; immunology; antibodies, monoclonal; dna; fibroblast; fibroblasts; chromosome translocation; chromosomes, human, pair 19; chromosomes, human, pair 1; ultrastructure; genetic marker; genetic markers; centromere; myotonic dystrophy; hybrid cell; hybrid cells; hamster; human; article; support, non-u.s. gov't; hamsters; translocation (genetics)
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