Expression of the Q8/9(d) gene by T cells of the mouse Journal Article
| Authors: | Matsuura, A.; Schloss, R.; Shen, F. W.; Tung, J. S.; Hunt, S. W. 3rd; Fisher, D. A.; Hood, L. E.; Boyse, E. A. |
| Article Title: | Expression of the Q8/9(d) gene by T cells of the mouse |
| Abstract: | The Q genes, specifying Qa antigens and situated in the extended part of the major histocompatibility complex (MHC) of the mouse, comprise a subgroup of MHC class I genes whose significance and function are still largely unknown. In screening a cDNA library made from the BALB/c inducer T-cell line Cl.Ly1-T1, we isolated 11 clones representing Q8/9, but none representing Q6 or Q7. Confirmatory evidence is given that the Q8/9 gene originated from fusion of the 5′ region of the Q8 gene with the 3′ region of the Q9 gene at a recombination site or hot spot in the vicinity of intron 4. Contrary to previous impressions that Q8/9 is an inert pseudogene, we find that the Q8/9 gene can be functional and encode a Qa-2,3 antigen. One variety of the 11 Q8/9 clones isolated lacked exon 5, which encodes the transmembrane domain of class I glycoproteins, and thus may account for secretion of a soluble form of Qa-2,3 antigen thought to be released by activated T cells. © 1989 Springer-Verlag. |
| Keywords: | genetics; nonhuman; molecular genetics; t lymphocyte; t-lymphocytes; animal cell; mouse; animal; mice; gene expression; mice, inbred balb c; physiology; molecular cloning; cloning, molecular; dna; amino acid sequence; molecular sequence data; nucleotide sequence; hla antigen class 1; histocompatibility antigens class i; base sequence; mouse strain; rna splicing; major histocompatibility antigen class 1; structural gene; restriction mapping; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; genes, structural; q surface antigens |
| Journal Title: | Immunogenetics |
| Volume: | 30 |
| Issue: | 3 |
| ISSN: | 0093-7711 |
| Publisher: | Springer |
| Date Published: | 1989-09-01 |
| Start Page: | 156 |
| End Page: | 161 |
| Language: | English |
| DOI: | 10.1007/bf02421200 |
| PUBMED: | 2789189 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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