MicroRNAs and Cancer: Short RNAs Go a Long Way Journal Article
| Authors: | Ventura, A.; Jacks, T. |
| Article Title: | MicroRNAs and Cancer: Short RNAs Go a Long Way |
| Abstract: | MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute to tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations of individual miRNAs are found in some tumors. Functional studies are now elucidating the mechanism of action of putative oncogenic and tumor suppressor miRNAs. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | gene deletion; nonhuman; neoplasms; animals; gene targeting; gene overexpression; metastasis; microrna; carcinogenesis; gene expression regulation; cancer inhibition; oncogene; tumor suppressor gene; messenger rna; rna, messenger; cell transformation; epigenesis, genetic; cancer cell; short survey; gene silencing; tumor growth; micrornas; genes, tumor suppressor; rna binding; rna sequence; carcinogens |
| Journal Title: | Cell |
| Volume: | 136 |
| Issue: | 4 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2009-02-20 |
| Start Page: | 586 |
| End Page: | 591 |
| Language: | English |
| DOI: | 10.1016/j.cell.2009.02.005 |
| PUBMED: | 19239879 |
| PROVIDER: | scopus |
| PMCID: | PMC3910108 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 54" - "Export Date: 30 November 2010" - "CODEN: CELLB" - "Source: Scopus" |
