Interplay between K-RAS and miRNAs Review


Authors: Shui, B.; La Rocca, G.; Ventura, A.; Haigis, K. M.
Review Title: Interplay between K-RAS and miRNAs
Abstract: K-RAS is frequently mutated in cancers, and its overactivation can lead to oncogene-induced senescence (OIS), a barrier to cellular transformation. Feedback onto K-RAS limits its signaling to avoid senescence while achieving the appropriate level of activation that promotes proliferation and survival. Such regulation could be mediated by miRNAs, as aberrant RAS signaling and miRNA activity coexist in several cancers, with miRNAs acting both up- and downstream of K-RAS. Several miRNAs both regulate and are regulated by K-RAS, suggesting a noncoding RNA-based feedback mechanism. Functional interactions between K-RAS and the miRNA machinery have also begun to unfold. This review comprehensively surveys the state of knowledge connecting K-RAS to miRNA function and proposes a model for the regulation of K-RAS signaling by noncoding RNAs. © 2022 Elsevier Inc.
Keywords: k-ras; mirna; cancer; feedback regulation
Journal Title: Trends in Cancer
Volume: 8
Issue: 5
ISSN: 2405-8025
Publisher: Cell Press  
Date Published: 2022-05-01
Start Page: 384
End Page: 396
Language: English
DOI: 10.1016/j.trecan.2022.01.002
PUBMED: 35093302
PROVIDER: scopus
PMCID: PMC9035052
DOI/URL:
Notes: Review -- Export Date: 25 April 2022 -- Source: Scopus
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  1. Andrea Ventura
    56 Ventura